{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:09:49Z","timestamp":1790467789966,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sporadic cerebral amyloid angiopathy shows progressive amyloid-\u03b2 deposition in the wall of small arterioles and capillaries of the leptomeninges and cerebral cortex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether amyloid load and distribution, assessed by florbetapir positron emission tomography (PET), differs between patients with probable CAA-related intracerebral hemorrhage (CAA-ICH) and mild cognitive impairment due to Alzheimer\u2019s disease (MCI-AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We assessed [\n                      <jats:sup>18<\/jats:sup>\n                      F]florbetapir uptake in 15 patients with probable CAA-ICH and 20 patients with MCI-AD patients. Global and regional florbetapir retention were assessed using standard uptake values ratio (SUVr) in region-based and voxel-wise approaches. Visual reading of florbetapir scans was performed for all participants. Group comparisons were performed using univariate and multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Global florbetapir retention was lower in patients with CAA-ICH than MCI-AD (median SUVr, 1.33 [1.21\u20131.41] versus 1.44 [1.35\u20131.66]; p\u200a=\u200a0.032). In the region-based analysis, regional florbetapir distribution was similar between the two groups. There was a trend for an increased occipital\/global ratio in CAA-ICH patients compared to MCI-AD ( p\u200a=\u200a0.060). In the voxel-wise approach, two clusters, one in parietal regions and the other in temporal regions, had higher uptake in MCI-AD relative to CAA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with CAA-ICH had a lower global florbetapir PET burden than patients with MCI-AD. Relative florbetapir retention in the posterior regions tended to be higher in CAA patients in region-based analysis but was not statistically different between groups. Investigation on differences in amyloid deposits distribution between groups required a fine-grained voxel-wise analysis. In future studies, selective amyloid tracers are needed to differentiate vascular from parenchymal amyloid.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190625","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T11:29:51Z","timestamp":1579001391000},"page":"1607-1614","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Florbetapir Regional Distribution in Cerebral Amyloid Angiopathy and Alzheimer\u2019s Disease: A PET Study"],"prefix":"10.1177","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-5858","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Planton","sequence":"first","affiliation":[{"name":"Department of Neurology, Toulouse University Hospital, Toulouse, France"},{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Saint-Aubert","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"},{"name":"Department of Nuclear Medicine, Imaging Center, Toulouse University Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Raposo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Toulouse University Hospital, Toulouse, France"},{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Payoux","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"},{"name":"Department of Nuclear Medicine, Imaging Center, Toulouse University Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Salabert","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"},{"name":"Department of Nuclear Medicine, Imaging Center, Toulouse University Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Albucher","sequence":"additional","affiliation":[{"name":"Department of Neurology, Toulouse University Hospital, Toulouse, France"},{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Olivot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Toulouse University Hospital, Toulouse, France"},{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"P\u00e9ran","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Pariente","sequence":"additional","affiliation":[{"name":"Department of Neurology, Toulouse University Hospital, Toulouse, France"},{"name":"Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm UMR1214, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301308"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003197"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cef7e3"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004228"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21164"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1186\/2191-219X-3-43"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700005742"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"ref010","first-page":"25","author":"Van der Linden M","year":"2004","journal-title":"L\u2019\u00e9valuation des troubles de la m\u00e9moire. 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