{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:33:10Z","timestamp":1785882790292,"version":"3.56.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,12,12]]},"DOI":"10.3233\/jad-190757","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T14:48:35Z","timestamp":1572360515000},"page":"1209-1216","source":"Crossref","is-referenced-by-count":58,"title":["Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial"],"prefix":"10.1177","volume":"72","author":[{"given":"Ryuji","family":"Ochiai","sequence":"first","affiliation":[{"name":"Biological Science Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Saitou","sequence":"additional","affiliation":[{"name":"Health Care Food Research Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Suzukamo","sequence":"additional","affiliation":[{"name":"Biological Science Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Osaki","sequence":"additional","affiliation":[{"name":"Health Care Food Research Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Asada","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-190757_ref1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/0891988706297469","article-title":"Attention and memory in the preclinical stage of dementia","volume":"20","author":"Silveri","year":"2007","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.3233\/JAD-190757_ref2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/jama.294.1.97","article-title":"Coffee consumption and risk of type 2 diabetes","volume":"294","author":"van Dam","year":"2005","journal-title":"JAMA"},{"key":"10.3233\/JAD-190757_ref3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/sj.ejcn.1602495","article-title":"Coffee consumption is inversely associated with cognitive decline in elderly European men: The FINE Study","volume":"61","author":"van Gelder","year":"2007","journal-title":"Eur J Clin Nutr"},{"key":"10.3233\/JAD-190757_ref4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ana.10277","article-title":"A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson\u2019s disease","volume":"52","author":"Hernan","year":"2002","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-190757_ref5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/mnfr.200400109","article-title":"Coffee consumption and human health \u2013 beneficial or detrimental? \u2013 Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus","volume":"49","author":"Ranheim","year":"2005","journal-title":"Mol Nutr Food Res"},{"key":"10.3233\/JAD-190757_ref6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/10408390903586412","article-title":"Coffee and its consumption: Benefits and risk","volume":"51","author":"Butt","year":"2011","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.3233\/JAD-190757_ref7","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1271\/bbb.130147","article-title":"Stimulation of postprandial fat utilization in healthy humans by daily consumption of chlorogenic acids","volume":"77","author":"Soga","year":"2013","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.3233\/JAD-190757_ref8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3945\/ajcn.113.069526","article-title":"Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men","volume":"99","author":"Lecoultre","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.3233\/JAD-190757_ref9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/09637486.2015.1007453","article-title":"Coffee bean polyphenols ameliorate postprandial endothelial dysfunction in healthy male adults","volume":"66","author":"Ochiai","year":"2015","journal-title":"Int J Food Sci Nutr"},{"key":"10.3233\/JAD-190757_ref10","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1002\/fsn3.861","article-title":"Effect of chlorogenic acids on fatigue and sleep in healthy males: A randomized, double-blind, placebo-controlled, crossover study","volume":"6","author":"Ochiai","year":"2018","journal-title":"Food Sci Nutr"},{"key":"10.3233\/JAD-190757_ref11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1179\/1476830514Y.0000000146","article-title":"Cognitive and neuroprotective effects of chlorogenic acid","volume":"20","author":"Heitman","year":"2017","journal-title":"Nutr Neurosci"},{"key":"10.3233\/JAD-190757_ref12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1271\/bbb.70670","article-title":"Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells","volume":"72","author":"Ito","year":"2008","journal-title":"Biosci Biotech Biochem"},{"key":"10.3233\/JAD-190757_ref13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1271\/bbb.130101","article-title":"Inhibition of amyloid beta aggregation by acteoside, a phenylethanoid glycoside","volume":"77","author":"Kurisu","year":"2013","journal-title":"Biosci Biotech Biochem"},{"key":"10.3233\/JAD-190757_ref14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejphar.2010.09.001","article-title":"neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice","volume":"649","author":"Kwon","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.3233\/JAD-190757_ref15","first-page":"8608497","article-title":"Effect of chlorogenic acid intake on cognitive function in the elderly: A pilot study","volume":"2018","author":"Kato","year":"2018","journal-title":"eCAM"},{"key":"10.3233\/JAD-190757_ref16","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3390\/nu10101337","article-title":"Effect of chlorogenic acids on cognitive function: A randomized double-blind placebo-controlled trial","volume":"10","author":"Saitou","year":"2018","journal-title":"Nutrients"},{"key":"10.3233\/JAD-190757_ref17","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): Current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.3233\/JAD-190757_ref18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/aje\/kwf119","article-title":"Coffee consumption and cognitive function among older adults","volume":"156","author":"Johnson-Kozlow","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.3233\/JAD-190757_ref19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: A preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-190757_ref20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1097-0010(19990301)79:3<362::AID-JSFA256>3.0.CO;2-D","article-title":"Chlorogenic acids and other cinnamates nature, occurrence and dietary burden","volume":"79","author":"Clifford","year":"1999","journal-title":"J Sci Food Agric"},{"key":"10.3233\/JAD-190757_ref21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.nutres.2013.11.001","article-title":"Coffee polyphenols improve peripheral endothelial function after glucose loading in healthy male adults","volume":"34","author":"Ochiai","year":"2014","journal-title":"Nutr Res"},{"key":"10.3233\/JAD-190757_ref22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.01.006","article-title":"Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials","volume":"31","author":"Clark","year":"2017","journal-title":"Sleep Med Rev"},{"key":"10.3233\/JAD-190757_ref23","first-page":"448","article-title":"The Alzheimer\u2019s disease assessment scale: An instrument for assessing treatment efficacy","volume":"19","author":"Mohs","year":"1983","journal-title":"Psychopharmacol Bull"},{"key":"10.3233\/JAD-190757_ref24","first-page":"129","article-title":"Trail making test errors in normal aging, mild cognitive impairment, and dementia","volume":"23","author":"Ashendorf","year":"2008","journal-title":"Arch Clin Neuropsychol"},{"key":"10.3233\/JAD-190757_ref25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1037\/h0063394","article-title":"The new Army individual test of general mental ability","volume":"41","author":"Staff, Personnel Research Section, Classification and Replacement Branch, AGO","year":"1944","journal-title":"Psychol Bull"},{"key":"10.3233\/JAD-190757_ref26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.acn.2004.02.005","article-title":"Assessment practices of clinical neuropsychologists in the United States and Canada: A survey of INS, NAN, and APA Division 40 members","volume":"20","author":"Rabin","year":"2005","journal-title":"Arch Clin Neuropsychol"},{"key":"10.3233\/JAD-190757_ref27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.intell.2011.03.001","article-title":"What cognitive abilities are involved in trail-making performance?","volume":"39","author":"Salthouse","year":"2011","journal-title":"Intelligence"},{"key":"10.3233\/JAD-190757_ref28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jchromb.2007.08.013","article-title":"Liquid chromatography-electrospray ionization-tandem mass spectrometry for simultaneous analysis of chlorogenic acids and their metabolites in human plasma","volume":"858","author":"Matsui","year":"2007","journal-title":"J Chromatography B"},{"key":"10.3233\/JAD-190757_ref29","first-page":"655","volume-title":"A compendium of neuropsychological tests: Administration, norms, and commentary","author":"Strauss","year":"2006"},{"key":"10.3233\/JAD-190757_ref30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/mnfr.201300349","article-title":"Dose-response plasma appearance of coffee chlorogenic and phenolic acids in adults","volume":"58","author":"Renouf","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"10.3233\/JAD-190757_ref31","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/hr.2009.132","article-title":"Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure","volume":"32","author":"Ochiai","year":"2009","journal-title":"Hypertens Res"},{"key":"10.3233\/JAD-190757_ref32","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/01.hjh.0000226196.67052.c0","article-title":"Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats","volume":"24","author":"Suzuki","year":"2006","journal-title":"J Hypertens"},{"key":"10.3233\/JAD-190757_ref33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/10641960600798655","article-title":"The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension","volume":"28","author":"Watanabe","year":"2006","journal-title":"Clin Exp Hypertens"},{"key":"10.3233\/JAD-190757_ref34","first-page":"2649","article-title":"Hydroxyhydroquinone-reduced milk coffee decreases blood pressure in individuals with mild hypertension and high-normal blood pressure","volume":"27","author":"Nagao","year":"2007","journal-title":"Prog Med"},{"key":"10.3233\/JAD-190757_ref35","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(13)61570-6","article-title":"A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the Cognitive Function and Ageing Study I and II","volume":"382","author":"Matthews","year":"2013","journal-title":"Lancet"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-190757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:07Z","timestamp":1777370827000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-190757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":35,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jad-190757","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,12]]}}}