{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:44:26Z","timestamp":1793763866231,"version":"4.6.1"},"reference-count":182,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disorder, marked by cortical and hippocampal deposition of amyloid-\u03b2 (A\u03b2) plaques and neurofibrillary tangles and cognitive impairment. Studies indicate a prominent link between cerebrovascular abnormalities and the onset and progression of AD, where blood-brain barrier (BBB) dysfunction and metabolic disorders play key risk factors. Pericyte degeneration, endothelial cell damage, astrocyte depolarization, diminished tight junction integrity, and basement membrane disarray trigger BBB damage. Subsequently, the altered expression of low-density lipoprotein receptor-related protein 1 and receptor for advanced glycation end products at the microvascular endothelial cells dysregulate A\u03b2 transport across the BBB. White matter lesions and microhemorrhages, dyslipidemia, altered brain insulin signaling, and insulin resistance contribute to tau and A\u03b2 pathogenesis, and oxidative stress, mitochondrial damage, inflammation, and hypoperfusion serve as mechanistic links between pathophysiological features of AD and ischemia. Deregulated calcium homeostasis, voltage gated calcium channel functioning, and protein kinase C signaling are also common mechanisms for both AD pathogenesis and cerebrovascular abnormalities. Additionally, APOE polymorphic alleles that characterize impaired cerebrovascular integrity function as primary genetic determinants of AD. Overall, the current review enlightens key vascular risk factors for AD and underscores pathophysiologic relationship between AD and vascular dysfunction.<\/jats:p>","DOI":"10.3233\/jad-190764","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T04:31:25Z","timestamp":1575520285000},"page":"39-58","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":82,"title":["Vascular Risk Factors and Alzheimer\u2019s Disease: Blood-Brain Barrier Disruption, Metabolic Syndromes, and Molecular Links"],"prefix":"10.1177","volume":"73","author":[{"given":"Jin-Ting","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The First Hospital of Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Ying","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"ref001","first-page":"269","volume":"167","author":"Teri L","year":"1997","journal-title":"West J Med"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074069"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181154"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180549"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00418"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.5.729"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-00899.1996"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2789"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1997.0164"},{"key":"ref012","first-page":"1435","volume":"137","author":"Kawai M","year":"1990","journal-title":"Am J Pathol"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.222"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1560-2"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.536839"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000143224.36527.44"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.76"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160527"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642016dn11-040005"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314697"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1123"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.01.005"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00966.2005"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480260305"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-05088.2003"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1074-9"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1126\/science.1971458"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.04.010"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.09.004"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx357"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.032"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152244"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.03.003"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.4161\/auto.20515"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.422964"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0297-y"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.2174\/187152709787601867"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2001-3105"},{"key":"ref039","first-page":"191863","volume":"2014","author":"Provias J","year":"2014","journal-title":"Int J Alzheimers Dis"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1080\/10611860290031831"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.10.063"},{"key":"ref042","first-page":"257953","volume":"2013","author":"Jeynes B","year":"2013","journal-title":"J Neurodegener Dis"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.2174\/156720508785908937"},{"key":"ref044","first-page":"672","volume":"10","author":"Schmidt AM","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10498"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100462"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1038\/nm890"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25247"},{"key":"ref049","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4288"},{"key":"ref050","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12004"},{"key":"ref051","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8593-x"},{"key":"ref052","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110725"},{"key":"ref053","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(02)00037-8"},{"key":"ref054","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.7.60"},{"key":"ref055","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.627562"},{"key":"ref056","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091965"},{"key":"ref057","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3966"},{"key":"ref058","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.03.003"},{"key":"ref059","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6102-11.2012"},{"key":"ref060","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERE.0000023612.66691.e6"},{"key":"ref061","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22527"},{"key":"ref062","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00068-X"},{"key":"ref063","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150716165726"},{"key":"ref064","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.10.015"},{"key":"ref065","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.03.039"},{"key":"ref066","doi-asserted-by":"publisher","DOI":"10.1159\/000017068"},{"key":"ref067","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132480"},{"key":"ref068","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.05.006"},{"key":"ref069","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303898"},{"key":"ref070","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31829a25b9"},{"key":"ref071","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.018"},{"key":"ref072","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600419"},{"key":"ref073","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1555-z"},{"key":"ref074","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0387-3"},{"key":"ref075","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.225532"},{"key":"ref076","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70005-4"},{"key":"ref077","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.27"},{"key":"ref078","first-page":"185","volume":"14","author":"Zhou H","year":"2014","journal-title":"Bosn J Basic Med Sci"},{"key":"ref079","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12655"},{"key":"ref080","doi-asserted-by":"publisher","DOI":"10.2174\/15672050113109990006"},{"key":"ref081","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.006"},{"key":"ref082","first-page":"415","volume":"317","author":"Kalaria RN","year":"1989","journal-title":"Prog Clin Biol Res"},{"key":"ref083","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350507"},{"key":"ref084","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091230"},{"key":"ref085","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1637"},{"key":"ref086","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.07.014"},{"key":"ref087","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1112"},{"key":"ref088","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.041"},{"key":"ref089","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140291.86406.D1"},{"key":"ref090","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0562"},{"key":"ref091","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-017-9991-9"},{"key":"ref092","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00490.2012"},{"key":"ref093","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0724-3"},{"key":"ref094","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.03.005"},{"key":"ref095","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0008"},{"key":"ref096","doi-asserted-by":"publisher","DOI":"10.1042\/BST0390939"},{"key":"ref097","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0112"},{"key":"ref098","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-016-9931-0"},{"key":"ref099","doi-asserted-by":"publisher","DOI":"10.2174\/156720512804142859"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16667364"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.297"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3012"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00054.x"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.11.1987"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04802.x"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1159\/000080027"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00189"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.1.1.507"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14130"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/986823"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02660-w"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-111262"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1954"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70085-7"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12629"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160640"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-017-9701-0"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.3233\/JAD-2012-129005","volume":"33","author":"Zhu X","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180772"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828250af"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000240285.89067.3f"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.11.032"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"ref124","first-page":"80","volume":"2","author":"Sun JH","year":"2014","journal-title":"Ann Transl Med"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-016-0224-5"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.01.002"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1632776.388"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-75"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-004-0274-0"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015242"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16654920"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02113-7"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9403-4"},{"key":"ref134","first-page":"19682","volume":"8","author":"Li JF","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00010"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00057-X"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-008-9294-x"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.03.030"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-26"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.164"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030831"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.17.1.17"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1159\/000330247"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330878"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.2.447S"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161141"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0440-6"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16662043"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-015-0288-1"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1038\/nature11729"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1636"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.16"},{"key":"ref153","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110284"},{"key":"ref154","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/504678"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.1179\/016164103101201940"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22055"},{"key":"ref157","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1041"},{"key":"ref158","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0515"},{"key":"ref159","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.09.086"},{"key":"ref160","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.05.003"},{"key":"ref161","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09988-3"},{"key":"ref162","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.11.041"},{"key":"ref163","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.08.002"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00557.2011"},{"key":"ref165","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011353"},{"key":"ref166","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv327"},{"key":"ref167","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20543"},{"key":"ref168","first-page":"123","volume":"61","author":"Wu HY","year":"2007","journal-title":"Acta Med Okayama"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8740-7"},{"key":"ref170","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00975-X"},{"key":"ref171","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12240"},{"key":"ref172","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.160"},{"key":"ref173","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)00203-S"},{"key":"ref174","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-0951"},{"key":"ref175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2009.12.014"},{"key":"ref176","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141422"},{"key":"ref177","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01229-2"},{"key":"ref178","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171193"},{"key":"ref179","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-011-0351-7"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.4161\/tisb.23993"},{"key":"ref181","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01098-13"},{"key":"ref182","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00806"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-190764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-190764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-190764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:14Z","timestamp":1777370834000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-190764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":182,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,7]]}},"alternative-id":["10.3233\/JAD-190764"],"URL":"https:\/\/doi.org\/10.3233\/jad-190764","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,2]]}}}