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In this study, brain metabolism and microstructure evaluated by high field (7 Tesla) proton magnetic resonance spectroscopy (\n                    <jats:sup>1<\/jats:sup>\n                    H-MRS) and diffusion tensor imaging (DTI) were evaluated in the limbic system of eight individuals with mild cognitive impairment (MCI), nine with AD, and sixteen normal elderly controls (NEC). Left hippocampal glutamate and posterior cingulate N-acetyl aspartate concentrations were reduced in MCI and AD compared to NEC. Differences in DTI metrics indicated volume and white matter loss along the cingulum in AD compared to NEC. Metabolic and microstructural changes were associated with episodic memory performance assessed using Craft Story 21 Recall and Benson Complex Figure Copy. The current study suggests that metabolite concentrations measured using\n                    <jats:sup>1<\/jats:sup>\n                    H-MRS may provide insight into the underlying metabolic and microstructural processes of episodic memory impairment.\n                  <\/jats:p>","DOI":"10.3233\/jad-190773","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T11:29:00Z","timestamp":1579001340000},"page":"1385-1405","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer\u2019s Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study"],"prefix":"10.1177","volume":"73","author":[{"given":"Dickson","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Medical Biophysics, University of 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