{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:36:40Z","timestamp":1784173000571,"version":"3.55.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Light to moderate alcohol consumption has been variably associated with lower or higher risk of dementia, but effects on Alzheimer\u2019s disease pathology are less clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We determined whether late-life alcohol consumption was associated with Alzheimer\u2019s disease pathology among older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We assessed the associations of alcohol consumption self-reported in 2000\u20132002 with brain amyloid-\u03b2 deposition on PET scans, and white matter lesion and hippocampal volume on MRIs measured 7\u20139 years later in 189 participants of the Ginkgo Evaluation of Memory Study (age 75\u201387 years at baseline) who were free of clinical dementia, using multivariable-adjusted and inverse probability-weighted robust linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Alcohol consumption was not statistically significantly associated with amyloid-\u03b2 deposition (standardized uptake value ratio difference per drink: \u20130.013 [95% CI: \u20130.027, 0.002]). Both non-drinkers and participants consuming \u22651 drink(s)\/week had higher white matter lesion volume (% intracranial volume) than did the reference group of those consuming &lt;1 drink\/week (differences: 0.25 % [95% CI: 0.01, 0.50]; 0.26 % [95% CI: 0.02, 0.50]). The association of alcohol consumption and hippocampal volume was modified by age ( p\u200a=\u200a0.02). Among participants younger than 77 years, participants consuming 1\u20137 drinks\/week had larger hippocampal volume compared with participants consuming &lt;1 drink\/week.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Alcohol consumption was not statistically significantly associated with amyloid-\u03b2 deposition 7\u20139 years later. Non-drinking and greater alcohol consumption were associated with higher white matter lesion volume compared with drinking &lt;1 drink\/week. Moderate drinking was associated with higher hippocampal volume in younger individuals. Given the selective nature of this population and adverse health effects of excessive alcohol consumption, these findings warrant further investigation, but cannot be translated into clinical recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190834","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T14:52:28Z","timestamp":1581087148000},"page":"509-519","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Alcohol Consumption, Brain Amyloid-\u03b2 Deposition, and Brain Structural Integrity Among Older Adults Free of Dementia"],"prefix":"10.1177","volume":"74","author":[{"given":"Manja","family":"Koch","sequence":"first","affiliation":[{"name":"Department of NutritionHarvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette L.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Departments of Family Medicine, Epidemiology, and Global Health, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar L.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"DeKosky","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis H.","family":"Kuller","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H.","family":"Mackey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majken K.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of NutritionHarvard T.H. Chan School of Public Health, Boston, MA, USA"},{"name":"Department of Medicine, Channing Division of Network Medicine, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Mukamal","sequence":"additional","affiliation":[{"name":"Department of NutritionHarvard T.H. Chan School of Public Health, Boston, MA, USA"},{"name":"Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.001"},{"key":"ref002","unstructured":"Dementia Fact sheet. WHO. 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