{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:45:56Z","timestamp":1785465956741,"version":"3.56.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although tooth loss is known to increase the risk of cognitive impairment and dementia, few studies have investigated the association between functional teeth including rehabilitated lost teeth and cognitive function<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated the associations of the numbers of functional teeth and functional occlusal units with cognitive impairment and cognitive function in late life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The current study was conducted as a part of the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), a community-based elderly cohort study. We analyzed 411 participants who have agreed with the additional dental exam. Geriatric psychiatrists and neuropsychologists administered the Consortium to Establish a Registry for Alzheimer\u2019s disease Assessment Packet Clinical and Neuropsychological Assessment Battery to all participants, and dentists examined their dental status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Higher number of functional teeth (OR\u200a=\u200a0.955, 95% CI\u200a=\u200a0.914\u20130.997, p\u200a=\u200a0.037) and higher number of functional occlusal units (OR\u200a=\u200a0.900, 95% CI\u200a=\u200a0.813\u20130.996, p\u200a=\u200a0.042) were associated with lower odds of cognitive impairment. When we analyzed these relationships separated by the location of teeth, only the numbers of functional teeth (OR\u200a=\u200a0.566, 95% CI\u200a=\u200a0.373\u20130.857, p\u200a=\u200a0.007) and functional occlusal units (OR\u200a=\u200a0.399, 95% CI\u200a=\u200a0.213\u20130.748, p\u200a=\u200a0.004) in the premolar area were associated with lower odds of cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Loss of functional teeth and functional occlusal units (especially in the premolar region) were associated with increased cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190971","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T09:27:36Z","timestamp":1579253256000},"page":"1313-1320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Loss of Functional Dentition is Associated with Cognitive Impairment"],"prefix":"10.1177","volume":"73","author":[{"given":"Ji Hyun","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Han","sequence":"additional","affiliation":[{"name":"Department of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yeol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Tae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dankook University College of Dentistry Jukjeon Dental Hospital, Yongin, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunha","family":"Yoo","sequence":"additional","affiliation":[{"name":"Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Hee","family":"Chang","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, 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