{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:10:17Z","timestamp":1777396217171,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Apolipoprotein E ( APOE) \u025b4 allele carriers have an increased risk of late-onset Alzheimer\u2019s disease (AD). However, in the \u201cChoosing Wisely\u201d campaign for avoiding unnecessary medical tests, treatments, and procedures, APOE genetic testing is not recommended as a predictive test for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the potential value of APOE genetic testing in a specific clinical context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Subjects with poor performance in the Korean version of the Mini-Mental Status Examination for dementia screening (MMSE-DS) with a Z-score of less than \u20131.5 were recruited from the public health centers. All participants underwent APOE genetic testing. Family history of dementia (FHx) was confirmed if one or more first-degree relatives had dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 349 subjects, 162 (46.4%) were diagnosed with AD. APOE \u025b4 allele carriers had a much higher risk of AD in the group with FHx than in the group without FHx (OR\u200a=\u200a15.81, 95% CI\u200a=\u200a2.74\u201391.21 versus OR\u200a=\u200a1.82, 95% CI\u200a=\u200a1.00\u20133.27, z\u200a=\u200a2.293, p\u200a=\u200a0.011). The sensitivity, specificity, positive predictive value, and negative predictive value for the APOE \u025b4 allele were 47.7%, 90.9%, 91.3%, and 46.5% in the group with FHx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It would be a wise choice to perform the APOE genetic testing for the diagnosis of AD in subjects with poor performance in a screening test and a family history of dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190983","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T13:05:25Z","timestamp":1584104725000},"page":"1253-1260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cChoosing Wisely\u201d: Apolipoprotein E Genetic Testing for the Diagnosis of Alzheimer\u2019s Disease in Dementia Clinics"],"prefix":"10.1177","volume":"74","author":[{"given":"Hyun Ju","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Ri","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea"},{"name":"Department of Neuropsychiatry, Jeju National University School of Medicine, Jeju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Eun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea"},{"name":"Department of Neuropsychiatry, Jeju National University School of Medicine, Jeju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Doo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea"},{"name":"Department of Neuropsychiatry, Jeju National University School of Medicine, Jeju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ghang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Korea University College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Public Health Science, Seoul National University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Won","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Woong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea"},{"name":"Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea"},{"name":"Department of Brain and Cognitive Sciences, Seoul National University, College of Natural Sciences, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea"},{"name":"Department of Neuropsychiatry, Jeju National University School of Medicine, Jeju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"ref001","unstructured":"World Health Organization (2012) News releases 2012, https:\/\/www.who.int\/mediacentre\/news\/releases\/2012\/dementia_20120411\/en\/, Accessed on June 30, 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