{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:07:55Z","timestamp":1777396075923,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,2,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recurrent ischemic stroke (IS) increases the risk of cognitive decline. To lower the risk of recurrent IS, secondary prevention is essential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our aim was to compare post-discharge secondary IS prevention and its maintenance up to 3 years after first IS in patients with and without Alzheimer\u2019s disease and other dementia disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective open-cohort study 2007\u20132014 from the Swedish national dementia registry (SveDem) and the Swedish national stroke registry (Riksstroke). Patients with dementia who experienced an IS ( n\u200a=\u200a1410; 332 [23.5%] with Alzheimer\u2019s disease) were compared with matched non-dementia IS patients ( n\u200a=\u200a7150). We analyzed antiplatelet, anticoagulant, blood pressure lowering, and statin treatment as planned medication initiation at discharge and actual dispensation of medications at first, second, and third year post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At discharge, planned initiation of medication was higher in patients with dementia compared to non-dementia patients for antiplatelets (OR with 95% CI for fully adjusted models 1.23 [1.02\u20131.48]) and lower for blood pressure lowering medication (BPLM; 0.57 [0.49\u20130.67]), statins (0.57 [0.50\u20130.66]), and anticoagulants (in patients with atrial fibrillation \u2013 AF; 0.41 [0.32\u20130.53]). When analysis for antiplatelets was stratified according to the presence of AF, ORs for receiving antiplatelets remained significant only in the presence of AF (in the presence of AF 1.56 [1.21\u20132.01], in patients without AF 0.99 [0.75\u20131.33]). Similar trends were observed in 1st, 2nd, and 3rd year post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dementia was a predictor of lower statin and BPLM use. Patients with dementia and AF were more likely to be prescribed antiplatelets and less likely to receive anticoagulants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-191011","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T11:08:23Z","timestamp":1577444903000},"page":"1013-1021","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Secondary Stroke Prevention After Ischemic Stroke in Patients with Alzheimer\u2019s Disease and Other Dementia Disorders"],"prefix":"10.1177","volume":"73","author":[{"given":"Eva","family":"Zupanic","sequence":"first","affiliation":[{"name":"Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden"},{"name":"Department of Neurology, University Medical Centre, Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica G.","family":"Kramberger","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden"},{"name":"Department of Neurology, University Medical Centre, Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"von Euler","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Clinical Science and Education, S\u00f6dersjukhuset and Department of Medicine, Solna, Stockholm, Sweden"},{"name":"Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Norrving","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Neurology, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Winblad","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden"},{"name":"Karolinska University Hospital, Theme Aging, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraj","family":"Secnik","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Fastbom","sequence":"additional","affiliation":[{"name":"Karolinska Institutet and Stockholm University, Department of Neurobiology, Care Sciences and Society, Aging Research Center (ARC), Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Eriksdotter","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital, Theme Aging, Stockholm, Sweden"},{"name":"Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Garcia-Ptacek","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge, Sweden"},{"name":"Department of Internal Medicine Section for Neurology, S\u00f6dersjukhuset, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70255-2"},{"key":"ref002","first-page":"437","volume":"11","author":"Esenwa C","year":"2015","journal-title":"Vasc Health Risk 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