{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:05:08Z","timestamp":1786946708022,"version":"build-2736575974"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Changes in resting state functional connectivity (rs-fc) occur in Alzheimer\u2019s disease (AD), but few longitudinal rs-fc studies have been performed. Most studies focus on single networks and not a global measure of rs-fc. Although the amyloid tau neurodegeneration (AT(N)) framework is increasingly utilized by the AD community, few studies investigated when global rs-fc signature changes occur within this model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>1) Identify a global rs-fc signature that differentiates cognitively normal (CN) individuals from symptomatic AD. 2) Assess when longitudinal changes in rs-fc occur relative to conversion to symptomatic AD. 3) Compare rs-fc with amyloid, tau, and neurodegeneration biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A global rs-fc signature composed of intra-network connections was longitudinally evaluated in a cohort of cognitively normal participants at baseline ( n\u200a=\u200a335). Biomarkers, including cerebrospinal fluid (A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      and tau), structural magnetic resonance imaging, and positron emission tomography were obtained.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Global rs-fc signature distinguished CN individuals from individuals who developed symptomatic AD. Changes occurred nearly four years before conversion to symptomatic AD. The global rs-fc signature most strongly correlated with markers of neurodegeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The global rs-fc signature changes near symptomatic onset and is likely a neurodegenerative biomarker. Rs-fc changes could serve as a biomarker for evaluating potential therapies for symptomatic conversion to AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-191039","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T09:56:30Z","timestamp":1583229390000},"page":"1085-1095","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Resting State Functional Connectivity Signature Differentiates Cognitively Normal from Individuals Who Convert to Symptomatic Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"74","author":[{"given":"Julie K.","family":"Wisch","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Roe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh M.","family":"Babulal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Hope Center, Washington University in Saint Louis, St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L.","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University in St. Louis St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA"},{"name":"Department of Radiology, Washington University in St. Louis St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau M.","family":"Ances","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA"},{"name":"Department of Radiology, Washington University in St. Louis St. Louis, MO, USA"},{"name":"Hope Center, Washington University in Saint Louis, St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004870"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:17:2:101"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.03.007"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006213"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100734"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235925100"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2008.01.027"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.025"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.2105"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.440"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3067-17.2018"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aafe"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3263-16.2017"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr025"},{"key":"ref021","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1001\/jamaneurol.2013.2934","volume":"70","author":"Wang L","year":"2013","journal-title":"JAMA Neurol"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000228230.26044.a4"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.07.022"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4249"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073377"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.013"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.026"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20730"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.11.058"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000196"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001401"},{"key":"ref032","first-page":"P1480","volume":"14","author":"Smith RX","year":"2018","journal-title":"Alzheimers Dement"},{"key":"ref033","first-page":"30","volume":"2","author":"Goh JOS","year":"2011","journal-title":"Aging Dis"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5698-11.2012"},{"key":"ref035","first-page":"3233","volume":"141","author":"Roe CM","year":"2018","journal-title":"Brain"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344552"},{"key":"ref037","unstructured":"R Core Development Team (2013),\n                      A language and environment for statistical computing\n                      ."},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.00456"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat7854"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.12.1763"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829d8599"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr115"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp453"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f11d85"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24546"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170261"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-191039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-191039","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-191039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:50Z","timestamp":1777370870000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-191039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,21]]}},"alternative-id":["10.3233\/JAD-191039"],"URL":"https:\/\/doi.org\/10.3233\/jad-191039","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]}}}