{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:38:57Z","timestamp":1789504737894,"version":"build-2803163510"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:p>Genetic predispositions associated with metabolism of the amyloid-\u03b2 protein precursor underlie familial Alzheimer\u2019s disease; a form of dementia characterized by early disease onset and elevated levels of cortical amyloid-\u03b2. Human exposure to aluminum is linked to the etiology of Alzheimer\u2019s disease and recent research measured a high content of aluminum in brain tissue in familial Alzheimer\u2019s disease. To elaborate upon this finding, we have obtained brain tissues from a Colombian cohort of donors with familial Alzheimer\u2019s disease. We have used established methods to measure the aluminum content of these tissues and we have compared the data with a recently measured dataset for control brain tissues. We report significantly higher levels of aluminum in brain tissues in donors with familial Alzheimer\u2019s disease than in control tissues from donors without neurological impairment or neurodegeneration. We have used aluminum-specific fluorescence microscopy along with complementary imaging for amyloid-\u03b2 to demonstrate a very high degree of co-localization of these two risk factors in brain tissue in familial Alzheimer\u2019s disease. Aluminum and amyloid-\u03b2 were co-located in senile plaques as well as vasculature, the latter resembling cerebral amyloid angiopathy. Aluminum was also found separately from amyloid-\u03b2 in intracellular compartments including glia and neuronal axons. The research has identified an arguably unique association between high brain aluminum content and amyloid-\u03b2 and allows postulation that genetic predispositions defining familial Alzheimer\u2019s disease underlie this relationship.<\/jats:p>","DOI":"10.3233\/jad-191140","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T11:31:24Z","timestamp":1579001484000},"page":"1627-1635","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":75,"title":["Aluminum and Amyloid-\u03b2 in Familial Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"73","author":[{"given":"Matthew","family":"Mold","sequence":"first","affiliation":[{"name":"The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Linhart","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy\/Pharmacognosy, University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"G\u00f3mez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Sede de Investigaci\u00f3n Universitaria SIU, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Villegas-Lanau","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Sede de Investigaci\u00f3n Universitaria SIU, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Exley","sequence":"additional","affiliation":[{"name":"The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198005000-00048"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1038\/360065a0"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1021\/ac970783f"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/375754a0"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340027028"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.12.001"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160648"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1039\/C1MT00139F"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-019-01710-0"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2017.11.012"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16122129"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87458-6"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310310"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-170010"},{"key":"ref017","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/0-387-23226-5_11","volume-title":"Alzheimer\u2019s Disease: Cellular and Molecular Aspects of Amyloid Beta","author":"Exley C","year":"2005"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16081459"},{"key":"ref019","first-page":"316","volume":"72","author":"Fleisher AS","year":"2015","journal-title":"JAMA"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-191140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-191140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-191140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:35Z","timestamp":1777370855000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-191140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,13]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,2,18]]}},"alternative-id":["10.3233\/JAD-191140"],"URL":"https:\/\/doi.org\/10.3233\/jad-191140","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,13]]}}}