{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:44:11Z","timestamp":1790214251533,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,5,19]]},"DOI":"10.3233\/jad-191257","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T13:35:04Z","timestamp":1586871304000},"page":"571-579","source":"Crossref","is-referenced-by-count":30,"title":["Association of Cerebral Microbleeds with Cognitive Decline: A Longitudinal Study"],"prefix":"10.1177","volume":"75","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Fifth People\u2019s Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-191257_ref1","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1093\/brain\/awl387","article-title":"Spontaneous brain microbleeds: Systematic review, subgroup analyses and standards for study design and reporting","volume":"130","author":"Cordonnier","year":"2007","journal-title":"Brain"},{"key":"10.3233\/JAD-191257_ref2","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1161\/STROKEAHA.112.655803","article-title":"Cerebrovascular disease and mechanisms of cognitive impairment: Evidence from clinicopathological studies in humans","volume":"43","author":"Kalaria","year":"2012","journal-title":"Stroke"},{"key":"10.3233\/JAD-191257_ref3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/alzrt263","article-title":"Cerebral microbleeds: Overview and implications in cognitive impairment","volume":"6","author":"Martinez-Ramirez","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-191257_ref4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/1531-8249(200002)47:2<145::AID-ANA3>3.0.CO;2-P","article-title":"Cerebral white matter lesions and cognitive function: The Rotterdam Scan Study","volume":"47","author":"de Groot","year":"2000","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-191257_ref5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1474-4422(09)70013-4","article-title":"Cerebral microbleeds: A guide to detection and interpretation","volume":"8","author":"Greenberg","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-191257_ref6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/STROKEAHA.110.607184","article-title":"Incidence of cerebral microbleeds in the general population: The Rotterdam Scan Study","volume":"42","author":"Poels","year":"2011","journal-title":"Stroke"},{"key":"10.3233\/JAD-191257_ref7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1212\/WNL.0000000000000692","article-title":"Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors","volume":"83","author":"Miwa","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-191257_ref8","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1212\/WNL.0b013e3182020349","article-title":"Cerebral microbleeds, retinopathy, and dementia: The AGES-Reykjavik Study","volume":"75","author":"Qiu","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-191257_ref9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1001\/archneurol.2011.93","article-title":"Lobar distribution of cerebral microbleeds: The Rotterdam Scan Study","volume":"68","author":"Mesker","year":"2011","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-191257_ref10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0022-3999(02)00428-2","article-title":"Frontal-subcortical neuronal circuits and clinical neuropsychiatry: An update","volume":"53","author":"Tekin","year":"2002","journal-title":"J Psychosom Res"},{"key":"10.3233\/JAD-191257_ref11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1159\/000368998","article-title":"Lobar microbleeds are associated with a decline in executive functioning in older adults","volume":"38","author":"Meier","year":"2014","journal-title":"Cerebrovasc Dis"},{"key":"10.3233\/JAD-191257_ref12","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1212\/WNL.0000000000003983","article-title":"Space and location of cerebral microbleeds, cognitive decline, and dementia in the community","volume":"88","author":"Ding","year":"2017","journal-title":"Neurology"},{"key":"10.3233\/JAD-191257_ref13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/WAD.0000000000000015","article-title":"Cerebral microbleeds and cognition: The epidemiology of dementia in Singapore study","volume":"28","author":"Hilal","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-191257_ref14","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3174\/ajnr.A4351","article-title":"Cerebral microbleeds, CSF p-Tau, and cognitive decline: Significance of anatomic distribution","volume":"36","author":"Chiang","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.3233\/JAD-191257_ref15","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.jalz.2013.05.1769","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative: A review of papers published since its inception","volume":"9","author":"Weiner","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-191257_ref16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jalz.2010.03.004","article-title":"Update on the magnetic resonance imaging core of the Alzheimer\u2019s Disease Neuroimaging Initiative","volume":"6","author":"Jack","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-191257_ref17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jalz.2010.03.003","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative positron emission tomography core","volume":"6","author":"Jagust","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-191257_ref18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1212\/WNL.0b013e3181cb3e25","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI): Clinical characterization","volume":"74","author":"Petersen","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-191257_ref19","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1007\/s11682-012-9186-z","article-title":"Development and assessment of a composite score for memory in the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI)","volume":"6","author":"Crane","year":"2012","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JAD-191257_ref20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s11682-012-9176-1","article-title":"A composite score for executive functioning, validated in Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment","volume":"6","author":"Gibbons","year":"2012","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JAD-191257_ref21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3233\/JAD-191005","article-title":"Associations of white matter hyperintensities with cognitive decline: A longitudinal study","volume":"73","author":"Wang","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-191257_ref22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jns.2010.08.034","article-title":"Cerebral microbleeds and vascular cognitive impairment","volume":"299","author":"Werring","year":"2010","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-191257_ref23","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1093\/brain\/awh253","article-title":"Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI","volume":"127","author":"Werring","year":"2004","journal-title":"Brain"},{"key":"10.3233\/JAD-191257_ref24","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamaneurol.2016.1017","article-title":"Association of cerebral microbleeds with cognitive decline and dementia","volume":"73","author":"Akoudad","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-191257_ref25","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/STROKEAHA.116.014166","article-title":"Strictly lobar cerebral microbleeds are associated with cognitive impairment","volume":"47","author":"Chung","year":"2016","journal-title":"Stroke"},{"key":"10.3233\/JAD-191257_ref26","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1161\/STROKEAHA.111.629634","article-title":"Frontal and temporal microbleeds are related to cognitive function: The Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study","volume":"42","author":"van Norden","year":"2011","journal-title":"Stroke"},{"key":"10.3233\/JAD-191257_ref27","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1212\/WNL.0b013e3182452928","article-title":"Cerebral microbleeds are associated with worse cognitive function: The Rotterdam Scan Study","volume":"78","author":"Poels","year":"2012","journal-title":"Neurology"},{"key":"10.3233\/JAD-191257_ref28","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/ana.23845","article-title":"Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment","volume":"73","author":"Park","year":"2013","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-191257_ref29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1212\/WNL.0b013e3181d3e3e9","article-title":"Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB","volume":"74","author":"Resnick","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JAD-191257_ref30","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/ana.410070516","article-title":"Pathological verification of ischemic score in differentiation of dementias","volume":"7","author":"Rosen","year":"1980","journal-title":"Ann Neurol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-191257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:59Z","timestamp":1777370879000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-191257"}},"subtitle":[],"editor":[{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":30,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-191257","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]}}}