{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:10:49Z","timestamp":1777396249741,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,4,21]]},"abstract":"<jats:p>\n                    We present the case of a patient with an atypical course of frontotemporal lobar degeneration (FTLD) complicated by the use of an anticholinergic drug. A 70-year-old patient, followed by psychiatrists for depression and behavioral disorders, received a diagnosis of dementia with Lewy bodies (DLB) at another Center due to auditory hallucinations, gait impairment, and tendency to fall. He was then admitted to our Memory Clinic Unit for behavioral disturbances, such as delusional thinking, auditory hallucinations, and memory complaints. At that time, the patient\u2019s therapy included Lorazepam, Quetiapine, Promazine, and Biperiden. The latter was immediately suspended for the absence of extrapyramidal signs and to avoid the anticholinergic cognitive side effects. A\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET showed a derangement of cortical metabolism with diffusely reduced activity, and limited areas of hyperactivity involving lateral frontal and lateral temporal inferior regions bilaterally. The patient underwent a series of exams, including neuropsychological tests,\n                    <jats:sup>123<\/jats:sup>\n                    I-MIBG scintigraphy, cerebrospinal fluid examination, and genetic analysis. A second\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET showed an extensive remodulation of metabolic activity: relative higher concentration of the tracer in the prefrontal and inferior temporal cortex was no more detectable. Similarly, the diffuse reduced metabolic activity could not be traced anymore. Nonetheless, the metabolic activity still appeared reduced in the frontal lobe, in the anterior cingulate bilaterally, and in the anterior part of the hemispheric fissure. Taken together, clinical and neuroimaging features would point to a FTLD-like form. Furthermore, the diagnostic work-up was likely confounded by the anticholinergic drug on\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET, highlighting the importance of carefully checking the patient\u2019s pharmacology during the diagnostic process.\n                  <\/jats:p>","DOI":"10.3233\/jad-191290","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T09:56:47Z","timestamp":1583229407000},"page":"1107-1117","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Cholinergic Derangement of Cortical Metabolism on\n                    <sup>18<\/sup>\n                    F-FDG PET in a Patient with Frontotemporal Lobar Degeneration Dementia: A Case of the TREDEM Registry"],"prefix":"10.1177","volume":"74","author":[{"given":"Maurizio","family":"Gallucci","sequence":"first","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Pallucca","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Di Battista","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bergamelli","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Fiore","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Boccaletto","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Perra","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Zanusso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[{"name":"University of Milan, Dino Ferrari Center, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Serpente","sequence":"additional","affiliation":[{"name":"University of Milan, Dino Ferrari Center, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"University of Milan, Dino Ferrari Center, Milan, Italy"},{"name":"Fondazione IRCCS Ca\u2019 Granda, Ospedale Policlinico, Neurodegenerative Disease Unit, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Imaging and Clinical Sciences and CESI, University G D\u2019Annunzio of Chieti-Pescara, Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1381735"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2017.01.008"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.2.140"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70065-1"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.75"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1080\/87565649109540545"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000118082"},{"key":"ref009","first-page":"1","volume":"6","author":"Spinnler H","year":"1987","journal-title":"Ital J Neurol Sci"},{"key":"ref010","unstructured":"ReyA (1964)\n                      L\u2019examen clinique en psychologie\n                      . 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