{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:15:00Z","timestamp":1782954900929,"version":"3.54.5"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"\n Background:<\/jats:title>\n Tau positron emission tomography (PET) imaging is used in research, but its relation to cerebrospinal fluid (CSF) tau and other Alzheimer\u2019s disease (AD)-related clinical measures is unclear in mild cognitive impairment with AD biomarkers (MCI-AD).<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n \n To determine associations between\n 18<\/jats:sup>\n F-flortaucipir PET and CSF AD biomarkers, cognitive functioning, and neuroimaging measures in MCI-AD.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n In 29 participants 50 years or older with MCI-AD,\n 18<\/jats:sup>\n F-flortaucipir PET, CSF total tau (T-tau), phosphorylated tau\n 181p<\/jats:sub>\n (P-tau), amyloid-\u03b2 (A\u03b2), structural MRI, and neuropsychological testing were collected as baseline assessments of an ongoing clinical trial.\n 11<\/jats:sup>\n C-Pittsburgh compound B PET was simultaneously conducted in 20 participants. Associations between\n 18<\/jats:sup>\n F-flortaucipir PET and these measures were assessed by multiple linear regression adjusted for potential confounders and using global, lobar, and voxel-wise standardized uptake value ratio (SUVr).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Whole brain\n 18<\/jats:sup>\n F-flortaucipir SUVr was significantly associated with CSF T-tau ( r\u200a=\u200a0.68, p\u200a<\u200a0.001) and P-tau ( r\u200a=\u200a0.42, p\u200a=\u200a0.04) after adjusting for age, sex, race, and education, with strongest associations in the temporal region (T-tau: r\u200a=\u200a0.69, p\u200a<\u200a0.001; P-tau: r\u200a=\u200a0.49, p\u200a=\u200a0.02). Voxel-wise analysis confirmed these regional associations.\n 18<\/jats:sup>\n F-flortaucipir PET was also associated with CSF A\u03b2 ( r\u200a=\u200a\u20130.45, p\u200a=\u200a0.03), episodic memory ( r\u200a=\u200a\u20130.61, p\u200a=\u200a0.001), visuospatial working memory ( r\u200a=\u200a\u20130.46, p\u200a=\u200a0.02), and brain cortical thickness ( r\u200a=\u200a\u20130.44, p\u200a=\u200a0.03) but not hippocampal volume. In the amyloid PET subset, although\n 11<\/jats:sup>\n C-PiB PET associated strongly with\n 18<\/jats:sup>\n F-flortaucipir ( r\u200a=\u200a0.79, p\u22640.001), associations were stronger between\n 11<\/jats:sup>\n C-PiB and key outcomes, compared to\n 18<\/jats:sup>\n F-flortaucipir.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n 18<\/jats:sup>\n F-flortaucipir PET is moderately associated with CSF AD biomarkers and other AD-related phenotypes. The associations in this MCI-AD sample are stronger than previously described in other populations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/jad-191330","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T09:24:53Z","timestamp":1581672293000},"page":"589-601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["18<\/sup>\n F-Flortaucipir PET Associations with Cerebrospinal Fluid, Cognition, and Neuroimaging in Mild Cognitive Impairment due to Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"74","author":[{"given":"Maureen","family":"Okafor","sequence":"first","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon A.","family":"Nye","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, Emory University, 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