{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:16:11Z","timestamp":1777396571696,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,9,29]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vascular risk factors have been associated with risk of Alzheimer\u2019s disease (AD) and volume loss of the hippocampus, but the associations with subfields of the hippocampus are understudied. Knowing if vascular risk factors contribute to hippocampal subfield atrophy may improve our understanding of vascular contributions to neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the associations between age, sex, and vascular risk factors with hippocampal subfields volumes on 7T MRI in older persons without dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From the Medea 7T study, 283 participants (67\u00b19 years, 68% men) without dementia had 7T brain MRI and hippocampal subfield segmentation. Subfields were automatically segmented on the 3D T2-weighted 7T images with ASHS software. Using linear mixed models, we estimated adjusted associations of age, sex, and vascular risk factors with z-scores of volumes of the entorhinal cortex (ERC), subiculum (SUB), Cornu Ammonis (CA)1, CA2, CA3, CA4, and dentate gyrus (DG), and tail as multivariate correlated outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Increasing age was associated with smaller volumes in all subfields, except CA4\/DG. Current smoking was associated with smaller ERC and SUB volumes; moderate alcohol use with smaller CA1 and CA4\/DG, obesity with smaller volumes of ERC, SUB, CA2, CA3, and tail; and diabetes mellitus with smaller SUB volume. Sex, former smoking, and hypertension were not associated with subfield volumes. When formally tested, no risk factor affected the subfield volumes differentially.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Several vascular risk factors were associated with smaller volumes of specific hippocampal subfields. However, no statistical evidence was found that subfields were differentially affected by these risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-200159","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T10:10:24Z","timestamp":1599559824000},"page":"1223-1239","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Vascular Risk Factors of Hippocampal Subfield Volumes in Persons without Dementia: The Medea 7T Study"],"prefix":"10.1177","volume":"77","author":[{"given":"Kim","family":"Blom","sequence":"first","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiberdina L.","family":"Koek","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten H.T.","family":"Zwartbol","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashid","family":"Ghaznawi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo J.","family":"Kuijf","sequence":"additional","affiliation":[{"name":"Image Sciences Institute, University Medical Center Utrecht and Utrecht University, Utrecht, \rthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo D.","family":"Witkamp","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Hendrikse","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam I.","family":"Geerlings","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the UCC-SMART Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,5]]},"reference":[{"key":"ref001","unstructured":"World Health Organization, Fact Sheet Dementia, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia, Last updated September 19, 2019, Accessed on October 8, 2019."},{"key":"ref002","unstructured":"World Health Organization, Alzheimer\u2019s Disease International (2012) Dementia, A public health priority."},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.07.152"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5372-8"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.27"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.002"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.01.004"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3085"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21557"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.021"},{"key":"ref011","unstructured":"Jellinek, Hoeveel alcohol bevat een standaardglas bier, wijn of sterke drank? 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