{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:37:22Z","timestamp":1783769842379,"version":"3.55.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,9,15]]},"abstract":"<jats:p>Background: Higher vitamin E intake has been widely related to lower risks of cognitive decline and dementia. Animal models suggest that this relationship might be (partially) explained by the protection of vitamin E against presynaptic protein oxidation. Objective: In this cross-sectional study, we aimed to examine the associations between brain tocopherols and presynaptic protein levels in elderly humans. Methods: We examined associations of \u03b1- and \u03b3-tocopherol brain levels with presynaptic protein levels in 113 deceased participants (age 88.5\u00b16.0 years, 45 (40%) female) from the prospective Memory and Aging project. Three distinct presynaptic proteins, a SNARE protein composite, a synaptotagmin synaptophysin composite and the protein-protein interaction between synaptosomal-associated protein 25 (SNAP-25), and syntaxin were measured in two cortical brain regions. Linear regression models assessed associations of brain tocopherols with presynaptic protein levels. Results: Higher brain \u03b3-tocopherol levels were associated with higher levels of the SNARE protein composite, complexin-I, complexin-II, the synaptotagmin synaptophysin composite, and septin-5 in the midfrontal cortex (B(SE)\u200a=\u200a0.272 to 0.412 (0.084 to 0.091), p\u200a&lt;\u200a0.001 to 0.003). When additionally adjusted for global Alzheimer\u2019s disease pathology, cerebral infarcts, and Lewy body disease pathology, these associations remained largely similar. No associations were found between \u03b1-tocopherol and presynaptic protein levels. Conclusion: In this cross-sectional study, we found higher brain \u03b3-tocopherol levels were associated with presynaptic protein levels in the midfrontal cortex. These results are consistent with a proposed role of vitamin E to maintain presynaptic protein levels.<\/jats:p>","DOI":"10.3233\/jad-200166","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T15:35:54Z","timestamp":1595950554000},"page":"619-627","source":"Crossref","is-referenced-by-count":12,"title":["Brain \u03b3-Tocopherol Levels Are Associated with Presynaptic Protein Levels in Elderly Human Midfrontal Cortex"],"prefix":"10.1177","volume":"77","author":[{"given":"Francisca A.","family":"de Leeuw","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Honer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Colombia, Vancouver, British Colombia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Department of Neurological Sciences and Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Clare","family":"Morris","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-200166_ref1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/ajcn.81.2.508","article-title":"Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change","volume":"81","author":"Morris","year":"2005","journal-title":"Am J Clin 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