{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:13:34Z","timestamp":1777396414389,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,6,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) begins decades before the onset of dementia. There is a need to investigate biomarkers of early AD for use in clinical trials and to facilitate early intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to determine whether changes in hippocampal subfield volumes in healthy middle-aged adults were associated with risk of future dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included 150 participants from the PREVENT-Dementia cohort, which recruited subjects aged 40\u201359 with or without a family history of dementia (FHD; included here were 81 with FHD and 69 without). Hippocampal subfield volumes were segmented from high resolution T2-weighted 3T MRI images taken at baseline and 2-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>FHD and greater 20 year-risk of dementia due to cardiovascular risk factors were both associated with lower CA1 volume. FHD was also associated with a relative increase in combined CA3, CA4, and dentate gyrus volume between baseline and follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CA1 atrophy may commence as early as middle-age in those with a high risk of future dementia, while increases in CA3, CA4, and dentate gyrus volume may be a response to early AD in the form of inflammation or neurogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-200238","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T13:20:04Z","timestamp":1589289604000},"page":"1211-1218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia"],"prefix":"10.1177","volume":"75","author":[{"given":"Anna","family":"McKeever","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvar F.","family":"Paris","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig W.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Centre for Dementia Prevention, University of Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Centre for Dementia Prevention, University of Edinburgh, UK"},{"name":"Inserm, University Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam D.","family":"Waldman","sequence":"additional","affiliation":[{"name":"Centre for Dementia Prevention, University of Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Wells","sequence":"additional","affiliation":[{"name":"The Centre for Psychiatry, Imperial College London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Busza","sequence":"additional","affiliation":[{"name":"Clinical Imaging Facility, Imperial College London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Carriere","sequence":"additional","affiliation":[{"name":"Inserm, University Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1177\/1756285612461679"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3885"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.08.033"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.08.008"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.036"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70537-3"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.6.747"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001893"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.02.008"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.190165"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22473"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100138"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1772"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.06.005"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140924"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.009"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.04.174"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224030"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015950108"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0375-9"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00178"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.08.002"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2634794100"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12304"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.08.017"}],"container-title":["Journal 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