{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:14:43Z","timestamp":1777396483585,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Rare variants in the low-density lipoprotein receptor related protein 10 gene ( LRP10) have recently been implicated in the etiology of Parkinson\u2019s disease (PD) and dementia with Lewy bodies (DLB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We searched for LRP10 variants in a new series of brain donors with dementia and Lewy pathology (LP) at autopsy, or dementia and parkinsonism without LP but with various other neurodegenerative pathologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sanger sequencing of LRP10 was performed in 233 donors collected by the Netherlands Brain Bank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Rare, possibly pathogenic heterozygous LRP10 variants were present in three patients: p.Gly453Ser in a patient with mixed Alzheimer\u2019s disease (AD)\/Lewy body disease (LBD), p.Arg151Cys in a DLB patient, and p.Gly326Asp in an AD patient without LP. All three patients had a positive family history for dementia or PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Rare LRP10 variants are present in some patients with dementia and different brain pathologies including DLB, mixed AD\/LBD, and AD. These findings suggest a role for LRP10 across a broad neurodegenerative spectrum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-200318","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T11:02:13Z","timestamp":1592910133000},"page":"1161-1170","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical and Pathological Phenotypes of\n                    <i>LRP10<\/i>\n                    Variant Carriers with Dementia"],"prefix":"10.1177","volume":"76","author":[{"given":"Leonie J. M.","family":"Vergouw","sequence":"first","affiliation":[{"name":"Erasmus MC, University Medical Center Rotterdam, Department of Neurology and Alzheimer Center,  Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke","family":"Geut","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam, the Netherlands"},{"name":"Netherlands Institute for Neuroscience, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Breedveld","sequence":"additional","affiliation":[{"name":"Erasmus MC, University Medical Center Rotterdam, Department of Clinical Genetics, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demy J. S.","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Erasmus MC, University Medical Center Rotterdam, Department of Clinical Genetics, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Quadri","sequence":"additional","affiliation":[{"name":"Erasmus MC, University Medical Center Rotterdam, Department of Clinical Genetics, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Netherlands Brain Bank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke J. M.","family":"Rozemuller","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Amsterdam Neuroscience,  Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Erasmus MC, University Medical Center Rotterdam, Department of Neurology and Alzheimer Center,  Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank Jan","family":"de Jong","sequence":"additional","affiliation":[{"name":"Erasmus MC, University Medical Center Rotterdam, Department of Neurology and Alzheimer Center,  Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma D. J.","family":"van de Berg","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Bonifati","sequence":"additional","affiliation":[{"name":"Erasmus MC, University Medical Center Rotterdam, Department of Clinical Genetics, Rotterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.07.009"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds335"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.01.020"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30287-X"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30179-0"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30401-0"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30399-5"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30407-1"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30400-9"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.08.030"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30402-2"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27693"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.05.037"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.04.016"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0042-15.2015"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-31"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.06.008"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101261"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.09.014"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1021\/bi001583s"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129047"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0523-2"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0366-2"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0871-6"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1509-x"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22981"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.146"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-01994-1"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000044"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.005"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-200318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-200318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-200318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:27Z","timestamp":1777370907000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-200318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8,4]]}},"alternative-id":["10.3233\/JAD-200318"],"URL":"https:\/\/doi.org\/10.3233\/jad-200318","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}