{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:15:30Z","timestamp":1777396530422,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p>Background: Alzheimer\u2019s disease is a complex disorder of unclear etiology that develops in the elderly population. It is a debilitating, progressive neurodegeneration for which disease-modifying therapies do not exist. Previous studies have suggested that, for a subset of patients, dysregulation in hemostasis might be one of the molecular mechanisms that ultimately leads to the development of neurodegeneration resulting in cognitive decline that represents the most prominent symptomatic characteristic of Alzheimer\u2019s disease. Objective: To examine a relationship between factors that are part of coagulation and anticoagulation pathways with cognitive decline that develops during Alzheimer\u2019s disease. Methods: SOMAscan assay was used to measure levels of coagulation\/anticoagulation factors V, VII, IX, X, Xa, XI, antithrombin III, protein S, protein C, and activated protein C in plasma samples obtained from three groups of subjects: 1) subjects with stable cognitively healthy function, 2) subjects with stable mild cognitive impairment, and 3) subjects diagnosed with probable Alzheimer\u2019s disease. Results: Our results show that protein levels of coagulation factor XI are significantly increased in patients who are diagnosed with probable Alzheimer\u2019s disease compared with cognitively healthy subjects or patients diagnosed with mild cognitive impairment. Furthermore, our results demonstrate that significant predictors of Alzheimer\u2019s-type diagnosis are factors IX and XI\u2014an increase in both factors is associated with a reduction in cognitive function. Conclusion: Our study justifies further investigations of biological pathways involving coagulation\/anticoagulation factors in relation to dementia, including dementia resulting from Alzheimer\u2019s-type neurodegeneration.<\/jats:p>","DOI":"10.3233\/jad-200358","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T16:37:35Z","timestamp":1597163855000},"page":"375-386","source":"Crossref","is-referenced-by-count":18,"title":["Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer\u2019s Disease Diagnosis"],"prefix":"10.1177","volume":"77","author":[{"given":"Edin","family":"Begic","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina"},{"name":"Department of Cardiology, General Hospital \u201cPrim.Dr. Abdulah Nakas\u201d, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suncica","family":"Hadzidedic","sequence":"additional","affiliation":[{"name":"Computer Science and Information Systems Department, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina"},{"name":"Department of Computer Science, Durham University, Durham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Obradovic","sequence":"additional","affiliation":[{"name":"Clinic for Emergency and Internal Medicine, Military Medical Academy, University of Defense, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijo","family":"Begic","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Pediatric Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirsada","family":"Causevic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-200358_ref1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.3233\/JAD-200358_ref2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.amjcard.2016.04.039","article-title":"Long-term population-based cerebral ischemic event and cognitive outcomes of direct oral anticoagulants compared with warfarin among long-term anticoagulated patients for atrial 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