{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:37:08Z","timestamp":1792489028125,"version":"4.5.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2022,5,3]]},"abstract":"<jats:p>Background: The relationship between Alzheimer\u2019s disease (AD) and periodontitis has been recently investigated with heterogenous results. Objective: This study aims to evaluate the oral health status and its relationship with cognitive impairment of participants, enrolled in the Zab\u00fat Aging Project, a community-based cohort study performed in a rural community in Sicily, Italy. Methods: A case-control study (20 subjects with AD, 20 with amnestic mild cognitive impairment [aMCI], and 20 controls) was conducted. The protocol included a comprehensive medical and cognitive-behavioral examination. Full-mouth evaluation, microbial analysis of subgingival plaque samples (by RT-PCR analysis), and oral health-related quality of life (OHR-QoL) were evaluated. Results: The decayed, missing, and filled teeth (DMFT) total score of AD subjects was significantly higher than aMCI (p\u200a=\u200a0.009) and controls (p\u200a=\u200a0.001). Furthermore, the \u201cM\u201d component of DMFT (i.e., the number of missing teeth) was significantly higher in AD than in aMCI (p\u200a&lt;\u200a0.001) and controls (p\u200a&lt;\u200a0.001). A Poisson regression model revealed that age (p\u200a&lt;\u200a0.001), male gender (p\u200a=\u200a0.001), and AD (p\u200a=\u200a0.001) were positively correlated with DMFT. Concerning oral microbial load, the presence of Fusobacterium nucleatum was significantly higher in AD than in controls (p\u200a=\u200a0.02), and a higher load of Treponema denticola was found in aMCI than with AD (p\u200a=\u200a0.004). OHR-QoL scores did not differ among the groups. Conclusion: The current research suggests that AD is associated with chronic periodontitis, which is capable of determining tooth loss due to the pathogenicity of Fusobacterium nucleatum. These data remain to be confirmed in larger population-based cohorts.<\/jats:p>","DOI":"10.3233\/jad-200385","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T12:19:50Z","timestamp":1591359590000},"page":"173-183","source":"Crossref","is-referenced-by-count":44,"title":["Oral Health Status in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer\u2019s Disease: Data from the Zab\u00fat Aging Project"],"prefix":"10.1177","volume":"87","author":[{"given":"Vera","family":"Panzarella","sequence":"first","affiliation":[{"name":"Department of Surgical, Oncological, and Oral Sciences, Sector of Oral Medicine \u201cValerio Margiotta\u201d; University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Mauceri","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological, and Oral Sciences, Sector of Oral Medicine \u201cValerio Margiotta\u201d; University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Baschi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Maniscalco","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Campisi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological, and Oral Sciences, Sector of Oral Medicine \u201cValerio Margiotta\u201d; University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Monastero","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-200385_ref1","unstructured":"World Health Organization (2015) World Report on Ageing and Health. pp. 1\u2013247."},{"key":"10.3233\/JAD-200385_ref2","first-page":"101","article-title":"Trends in aging\u2014 United States and worldwide","volume":"52","author":"Centers for Disease Control and Prevention (CDC)","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.3233\/JAD-200385_ref3","first-page":"261","article-title":"The Italian Dementia National Plan. 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