{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:45:41Z","timestamp":1780983941794,"version":"3.54.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,9,29]]},"abstract":"<jats:p>Down syndrome (DS) is the most common cause of intellectual disability in infants and has a well-known relationship with the Alzheimer\u2019s disease. The association between DS and the other pathologies of senescence, such as normal pressure hydrocephalus (NPH), has been poorly investigated. This series included two DS patients with NPH. In both cases, NPH symptoms were initially misdiagnosed as DS associated senescence. Patients were treated with ventricular-peritoneal shunt, showing a sustained improvement (1 and 4 years of follow-up). To our knowledge, this is the first description of the occurrence of NPH in adult patients with DS and surgical outcomes.<\/jats:p>","DOI":"10.3233\/jad-200409","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T16:41:45Z","timestamp":1597164105000},"page":"979-984","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Normal Pressure Hydrocephalus in Down Syndrome: The Report of Two Cases"],"prefix":"10.1177","volume":"77","author":[{"given":"Massimo","family":"Marano","sequence":"first","affiliation":[{"name":"Neurology, Neurophysiology and Neurobiology unit, Department of Medicine, University Campus Bio-Medico of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Pompucci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, S. 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