{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:29:55Z","timestamp":1788974995288,"version":"build-2803163510"},"reference-count":82,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,8,18]]},"abstract":"<jats:p>Background: Frontotemporal dementia (FTD) is a presenile neurodegenerative disease for which there is no effective pharmacological treatment. Recently, a link has been proposed between neuroinflammation and FTD. Objective: Here, we aim to investigate the effects of palmitoylethanolamide (PEA) combined with luteoline (PEA-LUT), an endocannabinoid with anti-inflammatory and neuroprotective effects, on behavior, cognition, and cortical activity in a sample of FTD patients. Methods: Seventeen patients with a diagnosis of probable FTD were enrolled. Cognitive and neurophysiological evaluations were performed at baseline and after 4 weeks of PEA-LUT 700\u200amg\u00d72\/day. Cognitive effects were assessed by Neuropsychiatric Inventory (NPI), Mini-Mental State Examination, Frontal Assessment Battery (FAB), Screening for Aphasia in Neurodegeneration, Activities of Daily Living-Instrumental Activities of Daily Living, and Frontotemporal Lobar Degeneration-modified Clinical Dementia Rating scale. To investigate in vivo neurophysiological effects of PEA-LUT, we used repetitive and paired-pulse transcranial magnetic stimulation (TMS) protocols assessing LTP-like cortical plasticity, short-interval intracortical inhibition, long-interval intracortical inhibition (LICI), and short-latency afferent inhibition. Moreover, we used TMS combined with EEG to evaluate the effects on frontal lobe cortical oscillatory activity. Results: Treatment with PEA-LUT was associated with an improvement in NPI and FAB scores. Neurophysiological evaluation showed a restoration of LICI, in particular at ISI 100\u200ams, suggesting a modulation of GABA(B) activity. TMS-EEG showed a remarkable increase of TMS-evoked frontal lobe activity and of high-frequency oscillations in the beta\/gamma range. Conclusion: PEA-LUT could reduce behavioral disturbances and improve frontal lobe functions in FTD patients through the modulation of cortical oscillatory activity and GABA(B)ergic transmission.<\/jats:p>","DOI":"10.3233\/jad-200426","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T13:53:31Z","timestamp":1593784411000},"page":"1297-1308","source":"Crossref","is-referenced-by-count":49,"title":["Effects of Palmitoylethanolamide Combined with Luteoline on Frontal Lobe Functions, High Frequency Oscillations, and GABAergic Transmission in Patients with Frontotemporal Dementia"],"prefix":"10.1177","volume":"76","author":[{"given":"Martina","family":"Assogna","sequence":"first","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"},{"name":"Tor Vergata Policlinic, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias Paolo","family":"Casula","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"},{"name":"Department of Clinical and Movement Neurosciences, University College London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Borghi","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bonn\u00ec","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Sam\u00e0","sequence":"additional","affiliation":[{"name":"Tor Vergata Policlinic, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Motta","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"D\u2019Acunto","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Porrazzini","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Minei","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caltagirone","sequence":"additional","affiliation":[{"name":"Santa Lucia Foundation, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Martorana","sequence":"additional","affiliation":[{"name":"Tor 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