{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:30:35Z","timestamp":1780104635061,"version":"3.54.0"},"reference-count":90,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:p>Background: Amyloid-\u03b2 accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer\u2019s disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer\u2019s continuum in the 2018 NIA-AA research framework. Objective: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus. Methods: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDA\u03b2+) and amyloidnegative SCD (SCD\u03b2\u2212) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVR=\u2ad6FBB). Results: ReHo was significantly higher (voxel-wise p &lt; 0.01, cluster-level p &lt; 0.05) in the bilateral precuneus for SCDA\u03b2+patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDA\u03b2+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDA\u03b2+) and precuneus SUVRFBB (both groups). Conclusion: While partial confounding influences due to a higher APOE \u03b54 carrier ratio among SCDA\u03b2+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-\u03b2 load, highlighting incipient pathology in stage 2 of the AD continuum.<\/jats:p>","DOI":"10.3233\/jad-200472","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T12:42:31Z","timestamp":1608036151000},"page":"493-509","source":"Crossref","is-referenced-by-count":19,"title":["Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status"],"prefix":"10.1177","volume":"79","author":[{"given":"Shumei","family":"Li","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the DELCODE Study\u00a0Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Daamen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Scheef","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"},{"name":"Department of Radiology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian C.","family":"Gaertner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Buchert","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"},{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Buchmann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany"},{"name":"Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany"},{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilian University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Catak","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilian University Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dobisch","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Ertl-Wagner","sequence":"additional","affiliation":[{"name":"Institute for Clinical Radiology, Ludwig-Maximilian University Munich, Munich, Germany"},{"name":"Department of Medical Imaging, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Essler","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Fliessbach","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"},{"name":"Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Dylan","family":"Haynes","sequence":"additional","affiliation":[{"name":"Bernstein Center for Computational Neuroscience, Charit\u00e9 - Universit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enise Irem","family":"Incesoy","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"},{"name":"Charit\u00e9 \u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Kilimann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Rostock\/Greifswald"},{"name":"Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd J.","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Rostock University Medical Centre, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charit\u00e9 - Universit\u00e4tsmedizin 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