{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:18:38Z","timestamp":1777396718335,"version":"3.51.4"},"reference-count":77,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,11,10]]},"abstract":"<jats:p>Mitochondrial dysfunction has been widely reported in several neurodegenerative disorders, including in the brains of patients with Alzheimer\u2019s disease (AD), Parkinson\u2019s disease, and Huntington disease. An increasing number of studies have implicated altered glucose and energy metabolism in patients with AD. There is compelling evidence of abnormalities in some of the key mitochondrial enzymes involved in glucose metabolism, including the pyruvate dehydrogenase and \u03b1-ketoglutarate dehydrogenase complexes, which play a great significance role in the pathogenesis of AD. Changes in some of the enzyme activities of the mitochondria found in AD have been linked with the pathology of amyloid-\u03b2 (A\u03b2). This review highlights the role of mitochondrial function in the production and clearance of A\u03b2 and how the pathology of A\u03b2 leads to a decrease in energy metabolism by affecting mitochondrial function.<\/jats:p>","DOI":"10.3233\/jad-200519","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T10:22:43Z","timestamp":1602238963000},"page":"505-514","source":"Crossref","is-referenced-by-count":26,"title":["Role of Mitochondrial Dysfunction in the Pathology of Amyloid-\u03b2"],"prefix":"10.1177","volume":"78","author":[{"given":"Zhenting","family":"Huang","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, Chongqing, China"},{"name":"Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yan","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, Chongqing, China"},{"name":"Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, Chongqing, China"},{"name":"Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, Chongqing, China"},{"name":"Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zou","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of 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