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Case analyses of aging World Trade Center responders suggests that a single severe exposure may also induce a neuropathologic response. The goal of this report was to explore the neuroscientific support for the hypothesis that inhaled particulate matter might cause an Alzheimer\u2019s-like neurodegenerative disease, in order to consider proposed mechanisms and latency periods linking inhaled particulate matter and neurodegeneration, and to propose new directions in this line of research.<\/jats:p>","DOI":"10.3233\/jad-200679","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T12:16:48Z","timestamp":1602850608000},"page":"871-886","source":"Crossref","is-referenced-by-count":33,"title":["Acute versus Chronic Exposures to Inhaled Particulate Matter and Neurocognitive Dysfunction: Pathways to Alzheimer\u2019s Disease or a Related Dementia"],"prefix":"10.1177","volume":"78","author":[{"given":"Minos","family":"Kritikos","sequence":"first","affiliation":[{"name":"Department of Family, Population and Preventive Medicine, Program in Public Health, Renaissance School of Medicine at Stony Brook, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel E.","family":"Gandy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaymie R.","family":"Meliker","sequence":"additional","affiliation":[{"name":"Department of Family, Population and Preventive Medicine, Program in Public Health, Renaissance School of Medicine at Stony Brook, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Luft","sequence":"additional","affiliation":[{"name":"World Trade Center Health and Wellness Program, Department of Medicine, Renaissance School of Medicine at Stony Brook, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean A.P.","family":"Clouston","sequence":"additional","affiliation":[{"name":"Department of Family, Population and Preventive Medicine, Program in Public Health, Renaissance School of Medicine at Stony Brook, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-200679_ref1","unstructured":"WHO (2016) Ambient air pollution: A global assessment of exposure and burden of disease. 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