{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:17:22Z","timestamp":1777396642960,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,10,13]]},"abstract":"<jats:p>Background: Growing evidence suggests that there may be a sex-specific biological risk for Alzheimer\u2019s disease (AD). Individuals with autosomal dominant AD due to a mutation (E280A) in Presenilin-1 (PSEN1) are genetically determined to develop early-onset dementia and thus, have few age-related risk factors for AD that are known to vary by sex (i.e., cardiovascular disease, menopause, life expectancy). Objective: Investigate sex differences in markers of cognition and neurodegeneration in autosomal dominant AD. Methods: We conducted a retrospective study in 19 cognitively-unimpaired PSEN1 mutation carriers (age range 20\u201344; 11 females), 11 symptomatic carriers (age range 42\u201356; 8 females), and 23 matched non-carriers family members (age range 20\u201350; 13 females). We examined hippocampal volume ratio, CERAD Total Score, and CERAD Word List (i.e., Learning, Delayed Recall, and Recognition). Mann-Whitney U tests, Spearman correlations and regression models were conducted. Results: There were no differential associations between age, CERAD Total Score, CERAD Word List\u2013Learning, Delayed Recall, Recognition, and hippocampal volume ratio in male and female carriers and non-carriers. Cognitively-unimpaired female carriers showed better CERAD Total scores and CERAD Word List-Learning than cognitively-unimpaired male carriers, despite having similar hippocampal volume ratios. The interaction of sex and hippocampal volume ratio did not predict cognitive performance across groups. Conclusion: Our preliminary findings suggest that cognitively-unimpaired female carriers showed a verbal memory reserve, and as disease progresses, female carriers did not exhibit a cognitive susceptibility to AD-related neurodegeneration. Future studies with larger samples of autosomal dominant AD are warranted to further understand sex differences in AD-related clinical and pathological markers.<\/jats:p>","DOI":"10.3233\/jad-200723","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T11:02:58Z","timestamp":1599562978000},"page":"1743-1753","source":"Crossref","is-referenced-by-count":17,"title":["Examining Sex Differences in Markers of Cognition and Neurodegeneration in Autosomal Dominant Alzheimer\u2019s Disease: Preliminary Findings from the Colombian Alzheimer\u2019s Prevention Initiative Biomarker Study"],"prefix":"10.1177","volume":"77","author":[{"given":"Clara","family":"Vila-Castelar","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmarie","family":"Guzm\u00e1n-V\u00e9lez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enmanuelle","family":"Pardilla-Delgado","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel F.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamile","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Baena","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua T.","family":"Fox-Fuller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Tirado","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Acosta-Baena","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Rios-Romenets","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica B.","family":"Langbaum","sequence":"additional","affiliation":[{"name":"Banner Alzheimer\u2019s Institute, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre N.","family":"Tariot","sequence":"additional","affiliation":[{"name":"Banner Alzheimer\u2019s Institute, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Lopera","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric M.","family":"Reiman","sequence":"additional","affiliation":[{"name":"Banner Alzheimer\u2019s Institute, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakeel T.","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medell\u00edn, 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