{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:17:23Z","timestamp":1777396643368,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,10,13]]},"abstract":"<jats:p>Background: The COVID-19 pandemic has brought great disruption to health systems worldwide. This affected ongoing clinical research, particularly among those most vulnerable to the pandemic, like dementia patients. Fundaci\u00f3 ACE is a research center and memory clinic based in Barcelona, Spain, one of the hardest-hit countries. Objective: To describe the ad-hoc strategic plan developed to cope with this crisis and to share its outcomes. Methods: We describe participants\u2019 clinical and demographic features. Additionally, we explain our strategic plan aimed at minimizing the impact on clinical trial research activities, which included SARS-CoV-2 RT-PCR and IgG serological tests to all participants and personnel. The outcomes of the plan are described in terms of observed safety events and drop-outs during the study period. Results: A total of 130 patients were participating in 16 active clinical trials in Fundaci\u00f3 ACE when the lockdown was established. During the confinement, we performed 1018 calls to the participants, which led to identify adverse events in 26 and COVID-19 symptoms in 6. A total of 83 patients (64%) could restart on-site visits as early as May 11, 2020. All SARS-CoV-2 RT-PCR diagnostic tests performed before on-site visits were negative and only three IgG serological tests were positive. Throughout the study period, we only observed one drop-out, due to an adverse event unrelated to COVID-19. Discussion: The plan implemented by Fundaci\u00f3 ACE was able to preserve safety and integrity of ongoing clinical trials. We must use the lessons learned from the pandemic and design crisis-proof protocols for clinical trials.<\/jats:p>","DOI":"10.3233\/jad-200750","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T06:16:56Z","timestamp":1601014616000},"page":"1805-1813","source":"Crossref","is-referenced-by-count":4,"title":["Managing Clinical Trials for Alzheimer\u2019s Disease During the COVID-19 Crisis: Experience at Fundaci\u00f3 ACE in Barcelona, Spain"],"prefix":"10.1177","volume":"77","author":[{"given":"Carla","family":"Abdelnour","sequence":"first","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"For the Research Center and Memory Clinic, Fundaci\u00f3 ACE IsabelHern\u00e1ndezab MontserratAlegretab PilarCa\u00f1abateab IsabelRodr\u00edguezab MaiteeRosende-Rocaa Juan PabloTartaria RogelioL\u00f3peza SilviaGila LilianaVargasa AnaMaule\u00f3na AnaEspinosaab GemmaOrtegaab AngelaSanabriaab EmilioAlarc\u00f3na MariolaMorenoa SilviaPrecklera NataliaRobertoa SergiValeroa Itziarde Rojasa SoniaMoreno-Grauab ElviraMart\u00edna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester","family":"Esteban de Antonio","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"P\u00e9rez-Cord\u00f3n","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asunci\u00f3n","family":"Lafuente","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Buend\u00eda","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Pancho","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Jofresa","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ibarria","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Cuevas","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Ca\u00f1ada","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Calvet","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Diego","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gonz\u00e1lez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Orellana","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Montrreal","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"de Jorge","sequence":"additional","affiliation":[{"name":"SYNLAB Diagn\u00f3stico Globales, SA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Marqui\u00e9","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Fundaci\u00f3 ACE, Institut Catal\u00e0 de Neuroci\u00e8ncies Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 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