{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:47:47Z","timestamp":1777394867157,"version":"3.51.4"},"reference-count":180,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,12,8]]},"abstract":"<jats:p>It is widely recognized that Alzheimer\u2019s disease (AD) has a complicate link to renin-angiotensin system (RAS). It is known that cerebrovascular disease has some connections with AD, but most of the studies are still conducted in parallel or independently. Although previous research came up with large number of hypotheses about the pathogenesis of AD, it does not include the mechanism of RAS-related regulation of AD. It has been found that many components of RAS have been changed in AD. For example, the multifunctional and high-efficiency vasoconstrictor Ang II and Ang III with similar effects are changed under the action of other RAS signal peptides; these signal peptides are believed to help improve nerve injury and cognitive function. These changes may lead to neuropathological changes of AD, and progressive defects of cognitive function, which are association with some hypotheses of AD. The role of RAS in AD gradually attracts our attention, and RAS deserved to be considered carefully in the pathogenesis of AD. This review discusses the mechanisms of RAS participating in the three current hypotheses of AD: neuroinflammation, oxidative stress and amyloid-\u03b2 protein (A\u03b2) hypothesis, as well as the drugs that regulate RAS systems already in clinical or in clinical trials. It further demonstrates the importance of RAS in the pathogenesis of AD, not only because of its multiple aspects of participation, which may be accidental, but also because of the availability of RAS drugs, which can be reused as therapies of AD.<\/jats:p>","DOI":"10.3233\/jad-200770","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T11:48:00Z","timestamp":1604663280000},"page":"1315-1338","source":"Crossref","is-referenced-by-count":5,"title":["Research Progress of Alzheimer\u2019s Disease Therapeutic Drugs: Based on Renin-Angiotensin System Axis"],"prefix":"10.1177","volume":"78","author":[{"given":"Xinquan","family":"Li","sequence":"first","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiting","family":"Xuan","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dabao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawu","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"},{"name":"Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"},{"name":"Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoru","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the Fifth Affiliated Hospital and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"},{"name":"Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Song","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"},{"name":"Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China"},{"name":"Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-200770_ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12576-019-00679-4","article-title":"Renin\u2013angiotensin system research: from molecules to the whole body","volume":"69","author":"Takimoto-Ohnishi","year":"2019","journal-title":"J Physiol Sci"},{"key":"10.3233\/JAD-200770_ref2","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/CIRCRESAHA.116.303587","article-title":"Hypertension: renin-angiotensin-aldosterone system alterations","volume":"116","author":"te Riet","year":"2015","journal-title":"Circ Res"},{"key":"10.3233\/JAD-200770_ref3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","article-title":"Role of brain renin angiotensin system in neurodegeneration: An update","volume":"27","author":"Abiodun","year":"2020","journal-title":"Saudi J Biol Sci"},{"key":"10.3233\/JAD-200770_ref4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fphar.2018.00440","article-title":"Targeting renin\u2013angiotensin system against Alzheimer\u2019s disease","volume":"9","author":"Gebre","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.3233\/JAD-200770_ref5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2174\/1567205014666171016101816","article-title":"Pharmacogenetics of angiotensin-converting enzyme inhibitors in patients with Alzheimer\u2019s disease dementia","volume":"15","author":"de Oliveira","year":"2018","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-200770_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2017.01.006","article-title":"Changes of renin-angiotensin system-related aminopeptidases in early stage Alzheimer\u2019s disease","volume":"89","author":"Gard","year":"2017","journal-title":"Exp Gerontol"},{"key":"10.3233\/JAD-200770_ref7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neubiorev.2018.05.005","article-title":"Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies","volume":"92","author":"Ho","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-200770_ref8","first-page":"1","article-title":"Physician practice patterns associated with diagnostic evaluation of patients with suspected mild cognitive impairment and Alzheimer\u2019s disease","volume":"2019","author":"Judge","year":"2019","journal-title":"Int J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12929-019-0524-y","article-title":"Alzheimer\u2019s disease: risk factors and potentially protective measures","volume":"26","author":"Silva","year":"2019","journal-title":"J Biomed Sci"},{"key":"10.3233\/JAD-200770_ref10","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.msec.2017.07.011","article-title":"Multifunctional biosynthesized silver nanoparticles exhibiting excellent antimicrobial potential against multi-drug resistant microbes along with remarkable anticancerous properties","volume":"80","author":"Jha","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"10.3233\/JAD-200770_ref11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0167-4943(97)00015-0","article-title":"Vascular disease risk factors and findings in patients with Alzheimer\u2019s disease","volume":"25","author":"Tariska","year":"1997","journal-title":"Arch Gerontol Geriatr"},{"key":"10.3233\/JAD-200770_ref12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3233\/JAD-2010-091579","article-title":"Alzheimer\u2019s disease is incurable but preventable","volume":"20","author":"de la Torre","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref13","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/HYP.0000000000000053","article-title":"Impact of hypertension on cognitive function: a scientific statement from the American Heart Association","volume":"68","author":"Iadecola","year":"2016","journal-title":"Hypertension"},{"key":"10.3233\/JAD-200770_ref14","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3233\/JAD-171119","article-title":"The coming of age of the angiotensin hypothesis in Alzheimer\u2019s disease: progress toward disease prevention and treatment?","volume":"62","author":"Kehoe","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref15","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.2174\/0929867325666180226102358","article-title":"RAS in the central nervous system: potential role in neuropsychiatric disorders","volume":"25","author":"Rocha","year":"2018","journal-title":"Curr Med Chem"},{"key":"10.3233\/JAD-200770_ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2017.08.055","article-title":"The renin angiotensin system and the brain: New develoments","volume":"46","author":"Farag","year":"2017","journal-title":"J Clin Neurosci"},{"key":"10.3233\/JAD-200770_ref17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.phrs.2017.06.005","article-title":"The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases","volume":"125","author":"Li","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.3233\/JAD-200770_ref18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pneurobio.2014.11.004","article-title":"The development of small molecule angiotensin IV analogs to treat Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"125","author":"Wright","year":"2015","journal-title":"Prog Neurobiol"},{"key":"10.3233\/JAD-200770_ref19","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2174\/0929866524666170728154459","article-title":"Vasodilator effect of angiotensin-(1-7) on vascular coronary bed of rats: role of mas, ACE and ACE2","volume":"24","author":"de Moraes","year":"2017","journal-title":"Protein Pept Lett"},{"key":"10.3233\/JAD-200770_ref20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3233\/JAD-181035","article-title":"Contributions by the brain renin-angiotensin system to memory, cognition, and Alzheimer\u2019s disease","volume":"67","author":"Wright","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref21","doi-asserted-by":"crossref","first-page":"e0206705","DOI":"10.1371\/journal.pone.0206705","article-title":"The association of multiple anti-hypertensive medication classes with Alzheimer\u2019s disease incidence across sex, race, and ethnicity","volume":"13","author":"Barthold","year":"2018","journal-title":"PLoS One"},{"key":"10.3233\/JAD-200770_ref22","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/01.STR.0000121642.53822.58","article-title":"Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats","volume":"35","author":"Stenman","year":"2004","journal-title":"Stroke"},{"key":"10.3233\/JAD-200770_ref23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.phrs.2019.04.029","article-title":"Neuroinflammation in hypertension: the renin-angiotensin system versus pro-resolution pathways","volume":"144","author":"Mowry","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.3233\/JAD-200770_ref24","doi-asserted-by":"crossref","first-page":"5868935","DOI":"10.1155\/2019\/5868935","article-title":"Antioxidant effects of oral ang-(1-7) restore insulin pathway and RAS components ameliorating cardiometabolic disturbances in rats","volume":"2019","author":"Figueiredo","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.3233\/JAD-200770_ref25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10571-015-0327-y","article-title":"Evidence to consider angiotensin II receptor blockers for the treatment of early Alzheimer\u2019s disease","volume":"36","author":"Saavedra","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-200770_ref26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11906-018-0810-1","article-title":"Integrative physiological aspects of brain RAS in hypertension","volume":"20","author":"de Morais","year":"2018","journal-title":"Curr Hypertens Rep"},{"key":"10.3233\/JAD-200770_ref27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrn.2017.48","article-title":"Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease","volume":"18","author":"Kisler","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-200770_ref28","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/ijcp.12626","article-title":"Impact of renin-angiotensin system-targeting antihypertensive drugs on treatment of Alzheimer\u2019s disease: a meta-analysis","volume":"69","author":"Ye","year":"2015","journal-title":"Int J Clin Pract"},{"key":"10.3233\/JAD-200770_ref29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/1533317517707288","article-title":"Elevated plasma abeta42 in cognitively impaired individuals taking ACE inhibitor antihypertensives","volume":"32","author":"Regenold","year":"2017","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"10.3233\/JAD-200770_ref30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2174\/0929866527666191230103739","article-title":"Renin-angiotensin system and Alzheimer\u2019s disease pathophysiology: From the potential interactions to therapeutic perspectives","volume":"27","author":"Ribeiro","year":"2020","journal-title":"Protein Pept Lett"},{"key":"10.3233\/JAD-200770_ref31","doi-asserted-by":"crossref","first-page":"8188","DOI":"10.1007\/s12035-018-0966-3","article-title":"Stimulation of ACE2\/ANG(1-7)\/Mas axis by diminazene ameliorates Alzheimer\u2019s disease in the D-Galactose-Ovariectomized rat model: Role of PI3K\/Akt pathway","volume":"55","author":"Kamel","year":"2018","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-200770_ref32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1037\/bne0000182","article-title":"Cognitive impairment in heart failure: A protective role for angiotensin-(1-7)","volume":"131","author":"Hay","year":"2017","journal-title":"Behav Neurosci"},{"key":"10.3233\/JAD-200770_ref33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nlm.2011.10.003","article-title":"Angiotensin-(1-7)\/Mas axis integrity is required for the expression of object recognition memory","volume":"97","author":"Lazaroni","year":"2012","journal-title":"Neurobiol Learn Mem"},{"key":"10.3233\/JAD-200770_ref34","doi-asserted-by":"crossref","first-page":"9076042","DOI":"10.1155\/2020\/9076042","article-title":"Electroacupuncture improved chronic cerebral hypoperfusion-Induced anxiety-like behavior and memory impairments in spontaneously hypertensive rats by downregulating the ACE\/Ang II\/AT1R Axis and upregulating the ACE2\/Ang-(1-7)\/MasR axis","volume":"2020","author":"Feng","year":"2020","journal-title":"Neural Plast"},{"key":"10.3233\/JAD-200770_ref35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fnagi.2017.00129","article-title":"Brain renin-angiotensin system and microglial polarization: Implications for aging and neurodegeneration","volume":"9","author":"Labandeira-Garcia","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-200770_ref36","doi-asserted-by":"crossref","first-page":"101295","DOI":"10.1016\/j.redox.2019.101295","article-title":"Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system","volume":"26","author":"Cui","year":"2019","journal-title":"Redox Biol"},{"key":"10.3233\/JAD-200770_ref37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fphys.2014.00439","article-title":"The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance","volume":"5","author":"Vajapey","year":"2014","journal-title":"Front Physiol"},{"key":"10.3233\/JAD-200770_ref38","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1039\/C8FO00057C","article-title":"\u03b1-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt\/Nrf2\/HO-1 and suppression of the NF-\u03baB pathway","volume":"9","author":"Huang","year":"2018","journal-title":"Food Funct"},{"key":"10.3233\/JAD-200770_ref39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.metabol.2019.03.006","article-title":"Angiotensin-(1-7), adipokines and inflammation","volume":"95","author":"Lelis","year":"2019","journal-title":"Metabolism"},{"key":"10.3233\/JAD-200770_ref40","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1002\/jcp.27267","article-title":"Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome activation","volume":"234","author":"You","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.3233\/JAD-200770_ref41","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2174\/138161212799436593","article-title":"Role of renin-angiotensin system in inflammation, immunity and aging","volume":"18","author":"Capettini","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.3233\/JAD-200770_ref42","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 inflammasome activation drives tau pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"10.3233\/JAD-200770_ref43","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bcp.2018.01.047","article-title":"Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor\/PI3K\/Akt\/BDNF pathway and inhibition of angiotensin II type-1 receptor\/NF-kappaB axis","volume":"151","author":"Rabie","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"10.3233\/JAD-200770_ref44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2471215","article-title":"Inflammasomes, autophagy, and cell death: the trinity of innate host defense against intracellular bacteria","volume":"2019","author":"Krakauer","year":"2019","journal-title":"Mediators Inflamm"},{"key":"10.3233\/JAD-200770_ref45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-017-3116-8","article-title":"Epigenetic modification of TLE1 induce abnormal differentiation in diabetic mice intestinal epithelium","volume":"438","author":"Xu","year":"2018","journal-title":"Mol Cell Biochem"},{"key":"10.3233\/JAD-200770_ref46","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3892\/ijmm.2017.3127","article-title":"Ferulic acid exerts neuroprotective effects against cerebral ischemia\/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo","volume":"40","author":"Ren","year":"2017","journal-title":"Int J Mol Med"},{"key":"10.3233\/JAD-200770_ref47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pneurobio.2018.12.006","article-title":"Comprehensive review of mechanisms of pathogenesis involved in Alzheimer\u2019s disease and potential therapeutic strategies","volume":"174","author":"Sharma","year":"2019","journal-title":"Prog Neurobiol"},{"key":"10.3233\/JAD-200770_ref48","doi-asserted-by":"crossref","first-page":"11903","DOI":"10.1038\/s41598-017-12074-3","article-title":"Ang-(1-7) is an endogenous beta-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy","volume":"7","author":"Teixeira","year":"2017","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-200770_ref49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/bph.12159","article-title":"ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis","volume":"169","author":"Simoes e Silva","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.3233\/JAD-200770_ref50","doi-asserted-by":"crossref","first-page":"13006","DOI":"10.1073\/pnas.1900152116","article-title":"Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs","volume":"116","author":"Wang","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-200770_ref51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.atherosclerosis.2015.11.017","article-title":"Angiotensin 1-7 significantly reduces diabetes-induced leukocyte recruitment both in vivo and in vitro","volume":"244","author":"Bossi","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.3233\/JAD-200770_ref52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3389\/fphar.2020.01169","article-title":"Cellular and molecular pathways of COVID-19 and potential points of therapeutic Intervention","volume":"11","author":"Hussman","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.3233\/JAD-200770_ref53","doi-asserted-by":"crossref","first-page":"112470","DOI":"10.1016\/j.jep.2019.112470","article-title":"Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R\/ACE2-Ang1-7-Mas axis in rat","volume":"250","author":"Dang","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.3233\/JAD-200770_ref54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol Rev"},{"key":"10.3233\/JAD-200770_ref55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.peptides.2017.08.008","article-title":"Pattern of Mas expression in acute and post-acute stage of nerve injury in mice","volume":"96","author":"Assis","year":"2017","journal-title":"Peptides"},{"key":"10.3233\/JAD-200770_ref56","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00011-015-0805-1","article-title":"ACE2 and Ang-(1-7) protect endothelial cell function and prevent early atherosclerosis by inhibiting inflammatory response","volume":"64","author":"Zhang","year":"2015","journal-title":"Inflamm Res"},{"key":"10.3233\/JAD-200770_ref57","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1161\/HYPERTENSIONAHA.113.01847","article-title":"Increasing angiotensin-(1-7) levels in the brain attenuates metabolic syndrome-related risks in fructose-fed rats","volume":"63","author":"Guimaraes","year":"2014","journal-title":"Hypertension"},{"key":"10.3233\/JAD-200770_ref58","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41419-017-0257-3","article-title":"Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.3233\/JAD-200770_ref59","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3109\/10715762.2016.1167277","article-title":"N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid \u03b2-induced neuronal oxidative damage in cortical neurons","volume":"50","author":"Cho","year":"2016","journal-title":"Free Radic Res"},{"key":"10.3233\/JAD-200770_ref60","doi-asserted-by":"crossref","first-page":"e71433","DOI":"10.1371\/journal.pone.0071433","article-title":"Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury","volume":"8","author":"Fang","year":"2013","journal-title":"PLoS One"},{"key":"10.3233\/JAD-200770_ref61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2016.07.017","article-title":"Vitamin D2 suppresses amyloid-\u03b2 25\u201335 induced microglial activation in BV2 cells by blocking the NF-\u03baB inflammatory signaling pathway","volume":"161","author":"Raha","year":"2016","journal-title":"Life Sci"},{"key":"10.3233\/JAD-200770_ref62","doi-asserted-by":"crossref","first-page":"962","DOI":"10.15252\/embr.201643519","article-title":"Posttranslational modification impact on the mechanism by which amyloid-\u03b2 induces synaptic dysfunction","volume":"18","author":"Grochowska","year":"2017","journal-title":"EMBO Rep"},{"key":"10.3233\/JAD-200770_ref63","doi-asserted-by":"crossref","first-page":"1527624","DOI":"10.1080\/10872981.2018.1527624","article-title":"The development of medical MOOCs in China: current situation and challenges","volume":"23","author":"Gong","year":"2018","journal-title":"Med Educ Online"},{"key":"10.3233\/JAD-200770_ref64","doi-asserted-by":"crossref","first-page":"e13851","DOI":"10.2196\/13851","article-title":"Massive open online course evaluation methods: systematic review","volume":"22","author":"Alturkistani","year":"2020","journal-title":"J Med Internet Res"},{"key":"10.3233\/JAD-200770_ref65","doi-asserted-by":"crossref","first-page":"115041","DOI":"10.1016\/j.bone.2019.115041","article-title":"The angiotensin converting enzyme 2\/angiotensin-(1-7)\/Mas Receptor axis as a key player in alveolar bone remodeling","volume":"128","author":"Queiroz-Junior","year":"2019","journal-title":"Bone"},{"key":"10.3233\/JAD-200770_ref66","first-page":"5018410","article-title":"BCL6 attenuates proliferation and oxidative stress of vascular smooth muscle cells in hypertension","volume":"2019","author":"Chen","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.3233\/JAD-200770_ref67","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/jpet.118.248831","article-title":"Molecular basis of the brain renin angiotensin system in cardiovascular and neurologic disorders: uncovering a key role for the astroglial angiotensin type 1 receptor AT1R","volume":"366","author":"Haspula","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"10.3233\/JAD-200770_ref68","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.3390\/molecules24081583","article-title":"Oxidative stress: A key modulator in neurodegenerative diseases","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules (Basel)"},{"key":"10.3233\/JAD-200770_ref69","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1039\/C8FO00795K","article-title":"Major compounds of red ginseng oil attenuate A\u03b225\u201335-induced neuronal apoptosis and inflammation by modulating MAPK\/NF-\u03baB pathway","volume":"9","author":"Lee","year":"2018","journal-title":"Food Funct"},{"key":"10.3233\/JAD-200770_ref70","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00019052-199412000-00013","article-title":"Metals and free radicals in neurodegeneration","volume":"7","author":"Olanow","year":"1994","journal-title":"Curr Opin Neurol"},{"key":"10.3233\/JAD-200770_ref71","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1055\/s-2005-923325","article-title":"[Oxidative stress and cardiovascular diseases]","volume":"130","author":"Bassenge","year":"2005","journal-title":"Dtsch Med Wochenschr"},{"key":"10.3233\/JAD-200770_ref72","doi-asserted-by":"crossref","first-page":"e22682","DOI":"10.1371\/journal.pone.0022682","article-title":"ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of auonomic function","volume":"6","author":"Blagosklonny","year":"2011","journal-title":"PLoS One"},{"key":"10.3233\/JAD-200770_ref73","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.freeradbiomed.2018.08.031","article-title":"TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro","volume":"126","author":"Manuneedhi Cholan","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.3233\/JAD-200770_ref74","doi-asserted-by":"crossref","first-page":"H19","DOI":"10.1152\/ajpheart.00974.2012","article-title":"Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons","volume":"305","author":"Case","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.3233\/JAD-200770_ref75","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1007\/s12035-017-0754-5","article-title":"Angiotensin receptor blockade by inhibiting glial activation promotes hippocampal neurogenesis via activation of Wnt\/beta-Catenin signaling in hypertension","volume":"55","author":"Bhat","year":"2018","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-200770_ref76","doi-asserted-by":"crossref","DOI":"10.1177\/1470320316672349","article-title":"Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons","volume":"17","author":"Ou","year":"2016","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"10.3233\/JAD-200770_ref77","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10571-019-00778-1","article-title":"Kinin B1 receptor blockade prevents angiotensin II-induced neuroinflammation and oxidative stress in primary hypothalamic neurons","volume":"40","author":"Parekh","year":"2020","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-200770_ref78","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s11064-015-1536-y","article-title":"Angiotensin II triggers apoptosis via enhancement of NADPH oxidase-dependent oxidative stress in a dopaminergic neuronal cell line","volume":"40","author":"Zhao","year":"2015","journal-title":"Neurochem Res"},{"key":"10.3233\/JAD-200770_ref79","doi-asserted-by":"crossref","first-page":"F1355","DOI":"10.1152\/ajprenal.00407.2014","article-title":"Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension","volume":"307","author":"Sasser","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.3233\/JAD-200770_ref80","doi-asserted-by":"crossref","first-page":"1271864","DOI":"10.1155\/2018\/1271864","article-title":"Losartan ameliorates calcium oxalate-induced elevation of stone-related proteins in renal tubular cells by Inhibiting NADPH oxidase and oxidative stress","volume":"2018","author":"Qin","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.3233\/JAD-200770_ref81","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/jcmm.12687","article-title":"Mas receptor mediates cardioprotection of angiotensin-(1-7) against Angiotensin II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress","volume":"20","author":"Lin","year":"2016","journal-title":"J Cell Mol Med"},{"key":"10.3233\/JAD-200770_ref82","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000333340","article-title":"side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons","volume":"10","author":"Mateos","year":"2012","journal-title":"Neurodegener Dis"},{"key":"10.3233\/JAD-200770_ref83","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1089\/neu.2019.6376","article-title":"Subcutaneous administration of angiotensin-(1-7) improves recovery after traumatic brain injury in mice","volume":"36","author":"Janatpour","year":"2019","journal-title":"J Neurotrauma"},{"key":"10.3233\/JAD-200770_ref84","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1111\/jcmm.13471","article-title":"ACE2-EPC-EXs protect ageing ECs against hypoxia\/reoxygenation-induced injury through the miR-18a\/Nox2\/ROS pathway","volume":"22","author":"Zhang","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.3233\/JAD-200770_ref85","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3233\/JAD-142802","article-title":"Drosophila models of Alzheimer\u2019s disease: advances, limits, and perspectives","volume":"45","author":"Bouleau","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref86","doi-asserted-by":"crossref","first-page":"S567","DOI":"10.3233\/JAD-179941","article-title":"The amyloid-\u03b2 oligomer hypothesis: beginning of the third decade","volume":"64","author":"Cline","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref87","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/jnc.13632","article-title":"The amyloid cascade hypothesis: are we poised for success or failure?","volume":"139 Suppl 2","author":"Karran","year":"2016","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-200770_ref88","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1021\/acschemneuro.8b00574","article-title":"Regulation of abetaPP glycosylation modification and roles of glycosylation on abetaPP cleavage in Alzheimer\u2019s disease","volume":"10","author":"Tao","year":"2019","journal-title":"ACS Chem Neurosci"},{"key":"10.3233\/JAD-200770_ref89","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.intimp.2019.01.054","article-title":"Genistein suppresses psoriasis-related inflammation through a STAT3-NF-\u03baB-dependent mechanism in keratinocytes","volume":"69","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.3233\/JAD-200770_ref90","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1016\/j.febslet.2012.09.004","article-title":"Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains","volume":"586","author":"Tian","year":"2012","journal-title":"FEBS Lett"},{"key":"10.3233\/JAD-200770_ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.075"},{"key":"10.3233\/JAD-200770_ref92","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/HYPERTENSIONAHA.118.11775","article-title":"Pleiotropic benefits of the angiotensin receptor blocker candesartan in a mouse model of Alzheimer disease","volume":"72","author":"Trigiani","year":"2018","journal-title":"Hypertension"},{"key":"10.3233\/JAD-200770_ref93","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12943-018-0882-1","article-title":"The role of YAP\/TAZ activity in cancer metabolic reprogramming","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol Cancer"},{"key":"10.3233\/JAD-200770_ref94","doi-asserted-by":"crossref","unstructured":"Kirouac L , Rajic AJ , Cribbs DH , Padmanabhan J (2017) Activation of Ras-ERK signaling and GSK-3 by amyloid precursor protein and amyloid beta facilitates neurodegeneration in Alzheimer\u2019s disease. eNeuro 4, ENEURO.0149-16.","DOI":"10.1523\/ENEURO.0149-16.2017"},{"key":"10.3233\/JAD-200770_ref95","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1471-4159.2008.05837.x","article-title":"Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death","volume":"108","author":"Noh","year":"2009","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-200770_ref96","doi-asserted-by":"crossref","first-page":"eaav0917","DOI":"10.1126\/scisignal.aav0917","article-title":"The RAS-ERK pathway: A route for couples","volume":"11","author":"Santos","year":"2018","journal-title":"Sci Signal"},{"key":"10.3233\/JAD-200770_ref97","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.4103\/1673-5374.255957","article-title":"Remodeling dendritic spines for treatment of traumatic brain injury","volume":"14","author":"Xiong","year":"2019","journal-title":"Neural Regen Res"},{"key":"10.3233\/JAD-200770_ref98","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fnagi.2016.00107","article-title":"Glycines from the APP GXXXG\/GXXXA transmembrane motifs promote formation of pathogenic A\u03b2 oligomers in cells","volume":"8","author":"Decock","year":"2016","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-200770_ref99","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1523\/JNEUROSCI.1549-07.2007","article-title":"Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition","volume":"27","author":"Zou","year":"2007","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-200770_ref100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1207\/S15327914NC330202","article-title":"p53-independent apoptosis induced by genistein in lung cancer cells","volume":"33","author":"Lian","year":"1999","journal-title":"Nutr Cancer"},{"key":"10.3233\/JAD-200770_ref101","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1172\/JCI66541","article-title":"Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer\u2019s-like cognitive decline","volume":"124","author":"Bernstein","year":"2014","journal-title":"J Clin Invest"},{"key":"10.3233\/JAD-200770_ref102","doi-asserted-by":"crossref","first-page":"16917","DOI":"10.3390\/ijms140816917","article-title":"ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer\u2019s disease","volume":"14","author":"AbdAlla","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-200770_ref103","doi-asserted-by":"crossref","first-page":"015101","DOI":"10.1063\/1.4938261","article-title":"Binding of ACE-inhibitors to in vitro and patient-derived amyloid-\u03b2 fibril models","volume":"144","author":"Bhavaraju","year":"2016","journal-title":"J Chem Phys"},{"key":"10.3233\/JAD-200770_ref104","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.ajpath.2013.01.053","article-title":"A\u03b243 is the earliest-depositing A\u03b2 species in APP transgenic mouse brain and is converted to A\u03b241 by two active domains of ACE","volume":"182","author":"Zou","year":"2013","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-200770_ref105","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3233\/JAD-180282","article-title":"Cerebrospinal fluid levels of angiotensin-converting enzyme are associated with amyloid-\u03b242 burden in Alzheimer\u2019s disease","volume":"64","author":"Rocha","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref106","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1258\/ebm.2011.010265","article-title":"Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells","volume":"236","author":"Hess","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.3233\/JAD-200770_ref107","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1523\/JNEUROSCI.5901-11.2012","article-title":"Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-\u03b21-42 oligomers are revealed in vivo by using a novel animal model","volume":"32","author":"Brouillette","year":"2012","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-200770_ref108","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fnagi.2014.00238","article-title":"Abeta degradation or cerebral perfusion? Divergent effects of multifunctional enzymes","volume":"6","author":"Miners","year":"2014","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-200770_ref109","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10571-015-0233-3","article-title":"Role of RAGE in Alzheimer\u2019s disease","volume":"36","author":"Cai","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-200770_ref110","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3748\/wjg.v25.i3.330","article-title":"NKX6.3 protects against gastric mucosal atrophy by downregulating beta-amyloid production","volume":"25","author":"Yoon","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.3233\/JAD-200770_ref111","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fendo.2011.00017","article-title":"Angiotensin II, a neuropeptide at the frontier between endocrinology and neuroscience: Is there a link between the angiotensin II type 2 receptor and Alzheimer\u2019s disease?","volume":"2","author":"Gallo-Payet","year":"2011","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.3233\/JAD-200770_ref112","doi-asserted-by":"crossref","first-page":"67","DOI":"10.11604\/pamj.2018.30.67.15632","article-title":"Neurosarco\u00efdose c\u00e9r\u00e9brale","volume":"30","author":"Berri","year":"2018","journal-title":"Pan Afr Med J"},{"key":"10.3233\/JAD-200770_ref113","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s12035-015-9260-9","article-title":"Angiotensin-(1-7) is reduced and inversely correlates with tau hyperphosphorylation in animal models of Alzheimer\u2019s disease","volume":"53","author":"Jiang","year":"2015","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-200770_ref114","doi-asserted-by":"crossref","first-page":"22902","DOI":"10.1021\/acsami.8b03788","article-title":"Food-safe modification of stainless steel food-processing surfaces to reduce bacterial biofilms","volume":"10","author":"Awad","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.3233\/JAD-200770_ref115","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3233\/JAD-150831","article-title":"Effects of hypertension and anti-hypertensive treatment on amyloid-beta (Abeta) plaque load and abeta-synthesizing and abeta-degrading enzymes in frontal cortex","volume":"50","author":"Ashby","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref116","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/bpa.12130","article-title":"Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies","volume":"24","author":"Miners","year":"2014","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-200770_ref117","doi-asserted-by":"crossref","first-page":"19862","DOI":"10.1074\/jbc.RA119.009449","article-title":"The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infection","volume":"294","author":"Banerjee","year":"2019","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-200770_ref118","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/WON.0000000000000455","article-title":"Effect of polyhexamethylene biguanide solution on bacterial load and biofilm in venous leg ulcers","volume":"45","author":"Borges","year":"2018","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"10.3233\/JAD-200770_ref119","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10571-019-00744-x","article-title":"The angiotensin type 1 receptor antagonist losartan prevents ovariectomy-induced cognitive dysfunction and anxiety-like behavior in long evans rats","volume":"40","author":"Campos","year":"2020","journal-title":"Cell Mol Neurobiol"},{"key":"10.3233\/JAD-200770_ref120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s13311-019-00723-6","article-title":"Intranasal losartan decreases perivascular beta amyloid, inflammation, and the decline of neurogenesis in hypertensive rats","volume":"16","author":"Drews","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.3233\/JAD-200770_ref121","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbi.2017.04.001","article-title":"Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer\u2019s disease mice","volume":"64","author":"Torika","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.3233\/JAD-200770_ref122","doi-asserted-by":"crossref","first-page":"100827","DOI":"10.1016\/j.isci.2020.100827","article-title":"Novel bacterial diversity and fragmented eDNA identified in hyperbiofilm-forming pseudomonas aeruginosa rugose small colony variant","volume":"23","author":"Deng","year":"2020","journal-title":"iScience"},{"key":"10.3233\/JAD-200770_ref123","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.1073\/pnas.1606323113","article-title":"Interbacterial signaling via Burkholderia contact-dependent growth inhibition system proteins","volume":"113","author":"Garcia","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-200770_ref124","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3233\/JAD-2011-110341","article-title":"Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer\u2019s disease: results of a randomized controlled trial","volume":"26","author":"Wharton","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref125","doi-asserted-by":"crossref","first-page":"e1000213","DOI":"10.1371\/journal.ppat.1000213","article-title":"Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms","volume":"4","author":"Gilmore","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.3233\/JAD-200770_ref126","first-page":"31","article-title":"Angiotensin-receptor blockers (ARBs) and risk of Alzheimer's disease: A meta-analysis","volume":"2020","author":"Oscanoa","year":"2020","journal-title":"Curr Clin Pharmacol"},{"key":"10.3233\/JAD-200770_ref127","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/antiox8050112","article-title":"The flavonoid quercetin induces AP-1 activation in FRTL-5 thyroid cells","volume":"8","author":"Giuliani","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.3233\/JAD-200770_ref128","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2011-110347","article-title":"Associations of anti-hypertensive treatments with Alzheimer\u2019s disease, vascular dementia, and other dementias","volume":"26","author":"Davies","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref129","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1192\/bjpo.bp.116.004184","article-title":"Associations of centrally acting ACE inhibitors with cognitive decline and survival in Alzheimer\u2019s disease","volume":"3","author":"Fazal","year":"2017","journal-title":"BJPsych Open"},{"key":"10.3233\/JAD-200770_ref130","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3343\/alm.2018.38.2.176","article-title":"Correlation of aminoglycoside consumption and amikacin- or gentamicin-resistant pseudomonas aeruginosa in long-term nationwide analysis: is antibiotic cycling an effective policy for reducing antimicrobial resistance?","volume":"38","author":"Kim","year":"2018","journal-title":"Ann Lab Med"},{"key":"10.3233\/JAD-200770_ref131","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.trci.2018.09.001","article-title":"Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer\u2019s disease","volume":"4","author":"Hu","year":"2018","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.3233\/JAD-200770_ref132","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/13813455.2011.635660","article-title":"Mitochondrial mitophagic mechanisms of myocardial matrix metabolism and remodelling","volume":"118","author":"Vacek","year":"2012","journal-title":"Arch Physiol Biochem"},{"key":"10.3233\/JAD-200770_ref133","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1039\/C5OB01599E","article-title":"Selective modification of the 3\u2032\u2032-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains","volume":"14","author":"Santana","year":"2016","journal-title":"Org Biomol Chem"},{"key":"10.3233\/JAD-200770_ref134","doi-asserted-by":"crossref","first-page":"1633194","DOI":"10.1080\/20002297.2019.1633194","article-title":"Bacterial biofilm composition in healthy subjects with and without caries experience","volume":"11","author":"Schoilew","year":"2019","journal-title":"J Oral Microbiol"},{"key":"10.3233\/JAD-200770_ref135","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.joen.2017.01.020","article-title":"Transcriptomics analysis reveals putative genes involved in biofilm formation and biofilm-associated drug resistance of enterococcus faecalis","volume":"43","author":"Seneviratne","year":"2017","journal-title":"J Endod"},{"key":"10.3233\/JAD-200770_ref136","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/1120009X.2019.1678913","article-title":"Sub-minimum inhibitory concentration ceftazidime inhibits Escherichia coli biofilm formation by influencing the levels of the ibpA gene and extracellular indole","volume":"32","author":"Sun","year":"2019","journal-title":"J Chemother"},{"key":"10.3233\/JAD-200770_ref137","doi-asserted-by":"crossref","first-page":"2010675","DOI":"10.1155\/2018\/2010675","article-title":"Signaling mechanisms of selective PPARgamma modulators in Alzheimer\u2019s disease","volume":"2018","author":"Govindarajulu","year":"2018","journal-title":"PPAR Res"},{"key":"10.3233\/JAD-200770_ref138","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12868-016-0281-8","article-title":"Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention","volume":"17","author":"Agca","year":"2016","journal-title":"BMC Neurosci"},{"key":"10.3233\/JAD-200770_ref139","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/psyg.12353","article-title":"Thiazide therapy is not related to any changes in cognitive function in older hypertensive patients with or without dementia: a 26-week follow-up study","volume":"19","author":"Kocyigit","year":"2019","journal-title":"Psychogeriatrics"},{"key":"10.3233\/JAD-200770_ref140","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.nbd.2014.04.018","article-title":"Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer\u2019s disease model","volume":"68","author":"Ongali","year":"2014","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-200770_ref141","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13046-015-0221-y","article-title":"Metabolic reprogramming: the emerging concept and associated therapeutic strategies","volume":"34","author":"Yoshida","year":"2015","journal-title":"J Exp Clin Cancer Res"},{"key":"10.3233\/JAD-200770_ref142","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1111\/ejn.14390","article-title":"Vascular and non-vascular contributors to memory reduction during traumatic brain injury","volume":"50","author":"Charkviani","year":"2019","journal-title":"Eur J Neurosci"},{"key":"10.3233\/JAD-200770_ref143","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.bbalip.2017.08.003","article-title":"Structural insight into lipopolysaccharide transport from the Gram-negative bacterial inner membrane to the outer membrane","volume":"1862","author":"Dong","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.3233\/JAD-200770_ref144","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/brain\/aws325","article-title":"Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride","volume":"136","author":"Arun","year":"2013","journal-title":"Brain"},{"key":"10.3233\/JAD-200770_ref145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-3-319-96445-4_14","article-title":"Blood-brain barrier integrity and clearance of amyloid-\u03b2 from the BBB","volume":"1097","author":"Cockerill","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.3233\/JAD-200770_ref146","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1523\/JNEUROSCI.3639-16.2017","article-title":"Disruption of bmal1 impairs blood-brain barrier integrity via pericyte dysfunction","volume":"37","author":"Nakazato","year":"2017","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-200770_ref147","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.3233\/JAD-200770_ref148","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.micpath.2018.08.021","article-title":"Biofilm formation in erythromycin-resistant Staphylococcus aureus and the relationship with antimicrobial susceptibility and molecular characteristics","volume":"124","author":"Sun","year":"2018","journal-title":"Microb Pathog"},{"key":"10.3233\/JAD-200770_ref149","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1474-4422(05)70150-2","article-title":"Statin therapy in Alzheimer\u2019s disease","volume":"4","author":"Kivipelto","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-200770_ref150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside modifying enzymes","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist Updat"},{"key":"10.3233\/JAD-200770_ref151","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fcimb.2020.00084","article-title":"5-methylindole potentiates aminoglycoside against gram-positive bacteria including staphylococcus aureus persisters under hypoionic conditions","volume":"10","author":"Sun","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"10.3233\/JAD-200770_ref152","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1179\/1743132813Y.0000000295","article-title":"The effects of valsartan on cognitive deficits induced by aluminum trichloride and d-galactose in mice","volume":"36","author":"Yang","year":"2014","journal-title":"Neurol Res"},{"key":"10.3233\/JAD-200770_ref153","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/HYPERTENSIONAHA.108.123612","article-title":"Continuous activation of renin-angiotensin system impairs cognitive function in renin\/angiotensinogen transgenic mice","volume":"53","author":"Inaba","year":"2009","journal-title":"Hypertension"},{"key":"10.3233\/JAD-200770_ref154","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.mce.2008.11.003","article-title":"NADPH oxidases and angiotensin II receptor signaling","volume":"302","author":"Garrido","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"10.3233\/JAD-200770_ref155","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/mdr.2018.0218","article-title":"Mechanisms of fluoroquinolone and aminoglycoside resistance in keratitis-associated Pseudomonas aeruginosa","volume":"25","author":"Thirumalmuthu","year":"2019","journal-title":"Microb Drug Resist"},{"key":"10.3233\/JAD-200770_ref156","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1523\/JNEUROSCI.0329-17.2017","article-title":"Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer\u2019s disease","volume":"37","author":"Royea","year":"2017","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-200770_ref157","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/HCO.0b013e3283620745","article-title":"Do angiotensin receptor blockers prevent Alzheimer\u2019s disease?","volume":"28","author":"Hajjar","year":"2013","journal-title":"Curr Opin Cardiol"},{"key":"10.3233\/JAD-200770_ref158","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00401-019-02098-6","article-title":"ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"139","author":"Evans","year":"2020","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-200770_ref159","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1111\/bph.14593","article-title":"Targeting amyloid clearance in Alzheimer\u2019s disease as a therapeutic strategy","volume":"176","author":"Nalivaeva","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.3233\/JAD-200770_ref160","doi-asserted-by":"crossref","first-page":"9760","DOI":"10.1074\/jbc.RA118.006420","article-title":"A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer\u2019s disease pathology in mice","volume":"294","author":"Liu","year":"2019","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-200770_ref161","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1134\/S0006297919110105","article-title":"Neutral endopeptidase (neprilysin) in therapy and diagnostics: yin and yang","volume":"84","author":"Feygina","year":"2019","journal-title":"Biochemistry (Moscow)"},{"key":"10.3233\/JAD-200770_ref162","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1172\/JCI31547","article-title":"Valsartan lowers brain \u03b2-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease","volume":"117","author":"Wang","year":"2007","journal-title":"J Clin Invest"},{"key":"10.3233\/JAD-200770_ref163","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1038\/onc.2011.576","article-title":"Metabolic reprogramming of the tumor","volume":"31","author":"Ferreira","year":"2012","journal-title":"Oncogene"},{"key":"10.3233\/JAD-200770_ref164","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.expneurol.2018.04.003","article-title":"Estrogen-related receptor alpha is involved in Alzheimer\u2019s disease-like pathology","volume":"305","author":"Tang","year":"2018","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-200770_ref165","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s11481-016-9703-8","article-title":"Angiotensin converting enzyme inhibitors ameliorate brain inflammation associated with microglial activation: possible implications for Alzheimer\u2019s disease","volume":"11","author":"Torika","year":"2016","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.3233\/JAD-200770_ref166","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.semcancer.2017.03.004","article-title":"Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment","volume":"43","author":"Dumas","year":"2017","journal-title":"Semin Cancer Biol"},{"key":"10.3233\/JAD-200770_ref167","doi-asserted-by":"crossref","first-page":"e2554","DOI":"10.1097\/MD.0000000000002554","article-title":"Comparison of the efficacy and safety of different ACE inhibitors in patients with chronic heart failure: A PRISMA-compliant network meta-analysis","volume":"95","author":"Sun","year":"2016","journal-title":"Medicine"},{"key":"10.3233\/JAD-200770_ref168","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/JAD-2012-120763","article-title":"The effects of ramipril in individuals at risk for Alzheimer\u2019s disease: results of a pilot clinical trial","volume":"32","author":"Wharton","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref169","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fncel.2018.00116","article-title":"Microglial activation is modulated by captopril: and studies","volume":"12","author":"Asraf","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"10.3233\/JAD-200770_ref170","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-150487","article-title":"Older adults taking AT1-receptor blockers exhibit reduced cerebral amyloid retention","volume":"50","author":"Nation","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref171","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2014.03.030","article-title":"Differential effects of angiotensin II receptor blockers on A\u03b2 generation","volume":"567","author":"Liu","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-200770_ref172","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/1470320312459977","article-title":"Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer\u2019s disease type: possible involvement of PPAR-gamma agonistic property","volume":"14","author":"Singh","year":"2013","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"10.3233\/JAD-200770_ref173","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/ajh.2010.241","article-title":"Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats","volume":"24","author":"Pelisch","year":"2011","journal-title":"Am J Hypertens"},{"key":"10.3233\/JAD-200770_ref174","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13195-017-0255-9","article-title":"Memory is preserved in older adults taking AT1 receptor blockers","volume":"9","author":"Ho","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-200770_ref175","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/archneurol.2012.1010","article-title":"Impact of angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series","volume":"69,","author":"Hajjar","year":"2012","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-200770_ref176","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2014.05.019","article-title":"Angiotensin-(1-7) improves cognitive function in rats with chronic cerebral hypoperfusion","volume":"1573","author":"Xie","year":"2014","journal-title":"Brain Res"},{"key":"10.3233\/JAD-200770_ref177","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13195-016-0217-7","article-title":"Angiotensin-converting enzyme 2 is reduced in Alzheimer\u2019s disease in association with increasing amyloid-\u03b2 and tau pathology","volume":"8","author":"Kehoe","year":"2016","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-200770_ref178","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroscience.2017.01.027","article-title":"Angiotensin-(1-7) administration attenuates Alzheimer\u2019s disease-like neuropathology in rats with streptozotocin-induced diabetes via Mas receptor activation","volume":"346","author":"Chen","year":"2017","journal-title":"Neuroscience"},{"key":"10.3233\/JAD-200770_ref179","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3233\/JAD-181000","article-title":"Chronic angiotensin 1-7 infusion prevents angiotensin-II-induced cognitive dysfunction and skeletal muscle injury in a mouse model of Alzheimer\u2019s disease","volume":"69","author":"Cao","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-200770_ref180","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1161\/HYPERTENSIONAHA.119.14431","article-title":"AT2R\u2019s (Angiotensin II Type 2 Receptor\u2019s) role in cognitive and cerebrovascular deficits in a mouse model of Alzheimer disease","volume":"75","author":"Royea","year":"2020","journal-title":"Hypertension"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-200770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:04:25Z","timestamp":1777370665000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-200770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,8]]},"references-count":180,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jad-200770","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,8]]}}}