{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:18:53Z","timestamp":1777396733921,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,11,10]]},"abstract":"<jats:p>Background: The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) is an increasingly utilized cognitive stress test designed to identify early cognitive changes associated with incipient neurodegenerative disease. Objective: To examine previously derived cut-points for cognitively unimpaired older adults that were suggestive of performance impairment on multiple subscales of the LASSI-L. These cut-points were applied to a new sample of older adults who were cognitive healthy controls (HC: n\u200a=\u200a26) and those on the Alzheimer\u2019s disease (AD) continuum from early stage mild cognitive impairment (EMCI: n\u200a=\u200a28), late stage MCI (LMCI: n = 18) to mild AD (AD: n\u200a=\u200a27). Methods: All participants were administered the LASSI-L. All cognitively impaired participants were PET amyloid positive which likely reflects underlying AD neuropathology, while cognitively normal counterparts were deemed to have amyloid negative scans. Results: There was a monotonic relationship between the number of deficits on LASSI-L subscales and independent classification of study groups with greater severity of cognitive impairment. Importantly, taken together, impairment on maximum learning ability and measures of proactive semantic interference (both reflected by cued recall and intrusion errors) correctly classified 74.1% of EMCI, 94.4% of LMCI, and 96.3% of AD. Only 7.7% of HC were incorrectly classified as having impairments. Conclusion: A modest number of LASSI-L subscales taking approximately 8 minutes to administer, had excellent discriminative ability using established cut-offs among individuals with presumptive stages of AD. This has potential implications for both clinical practice and clinical research settings targeting AD during early prodromal stages.<\/jats:p>","DOI":"10.3233\/jad-200790","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T12:17:25Z","timestamp":1602850645000},"page":"789-799","source":"Crossref","is-referenced-by-count":9,"title":["A Brief Version of the LASSI-L Detects Prodromal Alzheimer\u2019s Disease States"],"prefix":"10.1177","volume":"78","author":[{"given":"Elizabeth","family":"Crocco","sequence":"first","affiliation":[{"name":"Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"1Florida Alzheimer\u2019s Disease Research Center, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie E.","family":"Curiel-Cid","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"1Florida Alzheimer\u2019s Disease Research Center, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Kitaigorodsky","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian J.","family":"Gonz\u00e1lez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Zheng","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan","family":"Duara","sequence":"additional","affiliation":[{"name":"1Florida Alzheimer\u2019s Disease Research Center, Miami, FL, USA"},{"name":"Wien Center for Alzheimer\u2019s Disease and Memory Disorders, Mount Sinai Medical Center, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"},{"name":"1Florida Alzheimer\u2019s Disease Research Center, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-200790_ref1","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/j.jalz.2011.05.001","article-title":"Assessment of cognition in early dementia","volume":"7","author":"Silverberg","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-200790_ref2","first-page":"30","article-title":"Performance-based and observational assessments in clinical trials across the Alzheimer\u2019s disease spectrum","volume":"14","author":"Harvey","year":"2017","journal-title":"Innov Clin Neurosci"},{"key":"10.3233\/JAD-200790_ref3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/1073191117691608","article-title":"Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimer\u2019s disease","volume":"25","author":"Loewenstein","year":"2018","journal-title":"Assessment"},{"key":"10.3233\/JAD-200790_ref4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13195-016-0170-5","article-title":"Alzheimer\u2019s Disease Assessment Scale-Cognitive subscale variants in mild cognitive impairment and mild Alzheimer\u2019s disease: Change over time and the effect of enrichment strategies","volume":"8","author":"Podhorna","year":"2016","journal-title":"Alz Res Therapy"},{"key":"10.3233\/JAD-200790_ref5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3233\/JAD-170991","article-title":"The Alzheimer\u2019s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog): Modifications and responsiveness in pre-dementia populations. 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