{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:13:14Z","timestamp":1790201594633,"version":"4.1.0"},"reference-count":73,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,12,8]]},"abstract":"<jats:p>Background: To date, it remains unclear how amyloid plaques and neurofibrillary tangles are related to neural activation and, consequently, cognition in Alzheimer\u2019s disease (AD). Recent findings indicate that tau accumulation may drive hippocampal hyperactivity in cognitively normal aging, but it remains to be elucidated how tau accumulation is related to neural activation in AD. Objective: To determine whether the association between tau accumulation and hippocampal hyperactivation persists in mild cognitive impairment (MCI) and mild dementia or if the two measures dissociate with disease progression, we investigated the relationship between local tau deposits and memory-related neural activation in MCI and mild dementia due to AD. Methods: Fifteen patients with MCI or mild dementia due to AD underwent a neuropsychological assessment and performed an item memory task during functional magnetic resonance imaging. Cerebral tau accumulation was assessed using positron emission tomography and [18F]-AV-1451. Results: Entorhinal, but not global tau accumulation, was highly correlated with hippocampal activation due to visual item memory encoding and predicted memory loss over time. Neural activation in the posterior cingulate cortex and the fusiform gyrus was not significantly correlated with tau accumulation. Conclusion: These findings extend previous observations in cognitively normal aging, demonstrating that entorhinal tau continues to be closely associated with hippocampal hyperactivity and memory performance in MCI and mild dementia due to AD. Furthermore, data suggest that this association is strongest in medial temporal lobe structures. In summary, our data provide novel insights into the relationship of tau accumulation to neural activation and memory in AD.<\/jats:p>","DOI":"10.3233\/jad-200835","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T11:48:00Z","timestamp":1604663280000},"page":"1601-1614","source":"Crossref","is-referenced-by-count":18,"title":["Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"78","author":[{"given":"Nils","family":"Richter","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard N.","family":"Bischof","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Dronse","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Nellessen","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Neumaier","sequence":"additional","affiliation":[{"name":"Nuclear Chemistry, Institute of Neuroscience and Medicine (INM-5), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"Institute for Radiochemistry and Experimental Molecular Imaging, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Josef","family":"Langen","sequence":"additional","affiliation":[{"name":"Medical Imaging Physics, Institute of Neuroscience and Medicine (INM-4), Research Center J\u00fclich, J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"van Eimeren","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Kukolja","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and 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