{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:57:00Z","timestamp":1782489420652,"version":"3.54.5"},"reference-count":143,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,11,23]]},"abstract":"<jats:p>Neurodegenerative diseases called tauopathies, such as Alzheimer\u2019s disease (AD), frontotemporal dementia, progressive supranuclear palsy, and Parkinson\u2019s disease, among others, are characterized by the pathological processing and accumulation of tau protein. AD is the most prevalent neurodegenerative disease and is characterized by two lesions: neurofibrillary tangles (NFTs) and neuritic plaques. The presence of NFTs in the hippocampus and neocortex in early and advanced stages, respectively, correlates with the patient\u2019s cognitive deterioration. So far, no drugs can prevent, decrease, or limit neuronal death due to abnormal pathological tau accumulation. Among potential non-pharmacological treatments, physical exercise has been shown to stimulate the development of stem cells (SCs) and may be useful in early stages. However, this does not prevent neuronal death from the massive accumulation of NFTs. In recent years, SCs therapies have emerged as a promising tool to repopulate areas involved in cognition in neurodegenerative diseases. Unfortunately, protocols for SCs therapy are still being developed and the mechanism of action of such therapy remains unclear. In this review, we show the advances and limitations of SCs therapy. Finally, we provide a critical analysis of its clinical use for AD.<\/jats:p>","DOI":"10.3233\/jad-200863","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T19:26:02Z","timestamp":1633634762000},"page":"917-935","source":"Crossref","is-referenced-by-count":20,"title":["Current Status and Challenges of Stem Cell Treatment for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"84","author":[{"given":"Mar","family":"Pacheco-Herrero","sequence":"first","affiliation":[{"name":"Neuroscience Research Laboratory, Faculty of Health Sciences, Pontificia Universidad Cat\u00f3lica Madre y Maestra, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis O.","family":"Soto-Rojas","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, State of Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidy","family":"Reyes-Sabater","sequence":"additional","affiliation":[{"name":"Neuroscience Research Laboratory, Faculty of Health Sciences, Pontificia Universidad Cat\u00f3lica Madre y Maestra, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Garc\u00e9s-Ramirez","sequence":"additional","affiliation":[{"name":"Escuela Nacional de Ciencias Biol\u00f3gicas, Depto de Fisiolog\u00eda, Instituto Polit\u00e9cnico Nacional, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidel","family":"de la Cruz L\u00f3pez","sequence":"additional","affiliation":[{"name":"Escuela Nacional de Ciencias Biol\u00f3gicas, Depto de Fisiolog\u00eda, Instituto Polit\u00e9cnico Nacional, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Villanueva-Fierro","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, CIIDIR, Unidad Durango, Durango, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Luna-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"National Dementia BioBank, Ciencias Biol\u00f3gicas, Facultad de Estudios Superiores Cuautitl\u00e1n, UNAM, State of Mexico, Mexico"},{"name":"Banco Nacional de Cerebros-UNPHU, Universidad Nacional Pedro Henr\u00edquez Ure\u00f1a, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-200863_ref1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bcp.2013.12.024","article-title":"Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers","volume":"88","author":"Reitz","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.3233\/JAD-200863_ref2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2174\/15672050113109990155","article-title":"Epidemiology and etiology of Alzheimer\u2019s disease: From genetic to non-genetic factors","volume":"10","author":"Jiang","year":"2013","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-200863_ref3","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: Synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-200863_ref4","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid beta and tau at synapses in Alzheimer\u2019s disease","volume":"82","author":"Spires-Jones","year":"2014","journal-title":"Neuron"},{"key":"10.3233\/JAD-200863_ref5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","article-title":"Amyloid beta-peptide is produced by cultured cells during normal metabolism","volume":"359","author":"Haass","year":"1992","journal-title":"Nature"},{"key":"10.3233\/JAD-200863_ref6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13311-014-0313-y","article-title":"beta-Amyloid peptides and amyloid plaques in Alzheimer\u2019s disease","volume":"12","author":"Gouras","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.3233\/JAD-200863_ref7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00401-010-0679-9","article-title":"Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer\u2019s disease","volume":"119","author":"Gouras","year":"2010","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-200863_ref8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02932857","article-title":"The relationship between senile plaques and cerebral blood vessels in Alzheimer\u2019s disease and senile dementia. 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