{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:32:41Z","timestamp":1781019161020,"version":"3.54.1"},"reference-count":63,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,9,28]]},"abstract":"<jats:p>Background: Altered plasma levels of sphingolipids, including sphingomyelins (SM), have been found in mouse models of Alzheimer\u2019s disease (AD) and in AD patient plasma samples. Objective: This study assesses fourteen plasma SM species in a late-onset AD (LOAD) patient cohort (n\u200a=\u200a138). Methods: Specimens from control, preclinical, and symptomatic subjects were analyzed using targeted mass-spectrometry-based metabolomic methods. Results: Total plasma SM levels were not significantly affected by age or cognitive status. However, one metabolite that has been elevated in manifest AD in several recent studies, SM OHC14:1, was reduced significantly in pre-clinical AD and MCI relative to normal controls. Conclusion: We recommend additional comprehensive plasma lipidomics in experimental and clinical biospecimens related to LOAD that might advance the utility of plasma sphingomyelin levels in molecular phenotyping and interpretations of pathobiological mechanisms.<\/jats:p>","DOI":"10.3233\/jad-200871","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T13:45:25Z","timestamp":1628862325000},"page":"1161-1171","source":"Crossref","is-referenced-by-count":11,"title":["Plasma Sphingomyelins in Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"83","author":[{"given":"Gianna","family":"Fote","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA"},{"name":"Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Macciardi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo S.","family":"Fiandaca","sequence":"additional","affiliation":[{"name":"Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine School of Medicine, Irvine, CA, USA"},{"name":"Department of Neurological Surgery, University of California Irvine School of Medicine, Irvine, CA, USA"},{"name":"Department of Anatomy & Neurobiology, 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