{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:44:59Z","timestamp":1783950299885,"version":"3.55.0"},"reference-count":307,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2020,11,10]]},"abstract":"<jats:p>Alzheimer\u2019s and Parkinson\u2019s diseases (AD, PD) have a pediatric and young adult onset in Metropolitan Mexico City (MMC). The SARS-CoV-2 neurotropic RNA virus is triggering neurological complications and deep concern regarding acceleration of neuroinflammatory and neurodegenerative processes already in progress. This review, based on our MMC experience, will discuss two major issues: 1) why residents chronically exposed to air pollution are likely to be more susceptible to SARS-CoV-2 systemic and brain effects and 2) why young people with AD and PD already in progress will accelerate neurodegenerative processes. Secondary mental consequences of social distancing and isolation, fear, financial insecurity, violence, poor health support, and lack of understanding of the complex crisis are expected in MMC residents infected or free of SARS-CoV-2. MMC residents with pre-SARS-CoV-2 accumulation of misfolded proteins diagnostic of AD and PD and metal-rich, magnetic nanoparticles damaging key neural organelles are an ideal host for neurotropic SARS-CoV-2 RNA virus invading the body through the same portals damaged by nanoparticles: nasal olfactory epithelium, the gastrointestinal tract, and the alveolar-capillary portal. We urgently need MMC multicenter retrospective-prospective neurological and psychiatric population follow-up and intervention strategies in place in case of acceleration of neurodegenerative processes, increased risk of suicide, and mental disease worsening. Identification of vulnerable populations and continuous effort to lower air pollution ought to be critical steps.<\/jats:p>","DOI":"10.3233\/jad-200891","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T12:57:57Z","timestamp":1600433877000},"page":"479-503","source":"Crossref","is-referenced-by-count":29,"title":["Environmental Nanoparticles, SARS-CoV-2 Brain Involvement, and Potential Acceleration of Alzheimer\u2019s and Parkinson\u2019s Diseases in Young Urbanites Exposed to Air Pollution"],"prefix":"10.1177","volume":"78","author":[{"given":"Lilian","family":"Calder\u00f3n-Garcidue\u00f1as","sequence":"first","affiliation":[{"name":"The University of Montana, Missoula, MT, USA"},{"name":"Universidad del Valle de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Torres-Jard\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Ciencias de la Atm\u00f3sfera, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Franco-Lira","sequence":"additional","affiliation":[{"name":"Colegio de Bachilleres Militarizado, \u201cGeneral Mariano Escobedo\u201d, Monterrey, N.L., M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Kulesza","sequence":"additional","affiliation":[{"name":"Auditory Research Center, Lake Erie College of Osteopathic Medicine, Erie, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Gonz\u00e1lez-Maciel","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatr\u00eda, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Reynoso-Robles","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatr\u00eda, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Brito-Aguilar","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Garc\u00eda-Arreola","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Revueltas-Ficachi","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana Adriana","family":"Barrera-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Universidad del Valle de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griselda","family":"Garc\u00eda-Alonso","sequence":"additional","affiliation":[{"name":"Universidad del Valle de 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