{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:18:13Z","timestamp":1777393093185,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2009,3,9]]},"DOI":"10.3233\/jad-2009-0990","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T15:59:04Z","timestamp":1491407944000},"page":"565-575","source":"Crossref","is-referenced-by-count":10,"title":["Increase in p53 Protein Levels by Presenilin 1 Gene Mutations and its Inhibition by Secretase Inhibitors"],"prefix":"10.1177","volume":"16","author":[{"given":"Linqing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Ohyagi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsue","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Sakae","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Motomura","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Furuya","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Omuta Hospital, Omuta, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Takeda","sequence":"additional","affiliation":[{"name":"National Institute for Longevity Sciences, NCGG, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Tabira","sequence":"additional","affiliation":[{"name":"National Institute for Longevity Sciences, NCGG, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ichi","family":"Kira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-2009-0990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:59:29Z","timestamp":1777370369000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-2009-0990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-2009-0990","relation":{},"ISSN":["1875-8908","1387-2877"],"issn-type":[{"value":"1875-8908","type":"electronic"},{"value":"1387-2877","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3,9]]}}}