{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:22Z","timestamp":1790279122618,"version":"4.1.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:p>Background: Allele \u025b4 of the apolipoprotein (APOE \u22084) gene is the strongest known genetic risk factor for late-onset sporadic Alzheimer\u2019s disease. A possible relationship between vitamin D and APOE is not yet clear. Objective: In this exploratory, cross-sectional study, we examined the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and brain volumes and the associations of both serum levels of 25(OH)D and APOE polymorphism to brain volumes in 127 persons (mean age 66 years) with cognitive symptoms. Methods: All subjects were examined with fully automated software for MRI volumetry, NeuroQuant. Results: After adjustment for relevant covariates, higher serum 25(OH)D levels were associated with greater volumes of cortical gray matter on both left (p\u200a=\u200a0.02) and right (p\u200a=\u200a0.04) sides. When both 25(OH)D levels and APOE genotype were used as the main covariates, no significant associations were found between vitamin D level and brain volume in any of the 11 brain regions. In adjusted models, only homozygous but not heterozygous APOE \u22084 allele carriers had significantly larger inferior lateral ventricles (p\u200a=\u200a0.003) and smaller hippocampal volume (p\u200a=\u200a0.035) than those without \u025b4. Homozygous APOE \u22084 carriers also had significantly higher vitamin D levels (p\u200a=\u200a0.009) compared to persons without the APOE \u22084 allele. Conclusion: Higher vitamin D levels might have a preserving effect on cortical grey matter volume.<\/jats:p>","DOI":"10.3233\/jad-201018","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T20:19:41Z","timestamp":1606249181000},"page":"311-321","source":"Crossref","is-referenced-by-count":11,"title":["Vitamin D Levels, APOE Allele, and MRI Volumetry Assessed by NeuroQuant in Norwegian Adults with Cognitive Symptoms"],"prefix":"10.1177","volume":"79","author":[{"given":"Jelena Zugic","family":"Soares","sequence":"first","affiliation":[{"name":"Medical Department, Section of Geriatrics, Lovisenberg Diaconal Hospital, Nydalen, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Pettersen","sequence":"additional","affiliation":[{"name":"Medical Department, Section of Geriatrics, Lovisenberg Diaconal Hospital, Nydalen, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u016brat\u0117 \u0160altyt\u0117","family":"Benth","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Campus Ahus, University of Oslo, Blindern, Norway"},{"name":"Health Services Research Unit, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Geriatric medicine, Oslo University Hospital, Nydalen, Oslo, Norway"},{"name":"Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, T\u00f8nsberg, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Strobel","sequence":"additional","affiliation":[{"name":"Medical Department, Section of Geriatrics, Lovisenberg Diaconal Hospital, Nydalen, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Selb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Geriatric medicine, Oslo University Hospital, Nydalen, Oslo, Norway"},{"name":"Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, T\u00f8nsberg, Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"},{"name":"Karolinska Institutet, Department for Neurobiology, Caring Science and Society, Division of Clinical Geriatrics Novum Research Park, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-201018_ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S0007114513001840","article-title":"A systematic review of vitamin D status in populations worldwide","volume":"111","author":"Hilger","year":"2014","journal-title":"Br J Nutr"},{"key":"10.3233\/JAD-201018_ref2","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1126\/science.505004","article-title":"Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid","volume":"206","author":"Stumpf","year":"1979","journal-title":"Science"},{"key":"10.3233\/JAD-201018_ref3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","article-title":"Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain","volume":"29","author":"Eyles","year":"2005","journal-title":"J Chem Neuroanat"},{"key":"10.3233\/JAD-201018_ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-8993(84)91153-3","article-title":"Administration of 1,25-dihydroxyvitamin D3 results in the elevation of hippocampal seizure threshold levels in rats","volume":"298","author":"Siegel","year":"1984","journal-title":"Brain Res"},{"key":"10.3233\/JAD-201018_ref5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00496810","article-title":"1,25 (OH)2 vitamin D3 sites of action in the brain. 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