{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:23:11Z","timestamp":1779891791809,"version":"3.53.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,3,23]]},"abstract":"<jats:p>Background: Red blood cells (RBCs) contain the majority of \u03b1-synuclein (\u03b1-syn) in blood, representing an interesting model for studying the peripheral pathological alterations proved in neurodegeneration. Objective: The current study aimed to investigate the diagnostic value of total \u03b1-syn, amyloid-\u03b2 (A\u03b21\u201342), tau, and their heteroaggregates in RBCs of Lewy body dementia (LBD) and Alzheimer\u2019s disease (AD) patients compared to healthy controls (HC). Methods: By the use of enzyme-linked immunosorbent assays, RBCs concentrations of total \u03b1-syn, A\u03b21\u201342, tau, and their heteroaggregates (\u03b1-syn\/A\u03b21\u201342 and \u03b1-syn\/tau) were measured in 27 individuals with LBD (Parkinson\u2019s disease dementia, n\u200a=\u200a17; dementia with Lewy bodies, n\u200a=\u200a10), 51 individuals with AD (AD dementia, n\u200a=\u200a37; prodromal AD, n\u200a=\u200a14), and HC (n\u200a=\u200a60). Results: The total \u03b1-syn and tau concentrations as well as \u03b1-syn\/tau heterodimers were significantly lower in the LBD group and the AD group compared with HC, whereas \u03b1-syn\/A\u03b21\u201342 concentrations were significantly lower in the AD dementia group only. RBC \u03b1-syn\/tau heterodimers had a higher diagnostic accuracy for differentiating patients with LBD versus HC (AUROC\u200a=\u200a0.80). Conclusion: RBC \u03b1-syn heteromers may be useful for differentiating between neurodegenerative dementias (LBD and AD) and HC. In particular, RBC \u03b1-syn\/tau heterodimers have demonstrated good diagnostic accuracy for differentiating LBD from HC. However, they are not consistently different between LBD and AD. Our findings also suggest that \u03b1-syn, A\u03b21\u201342, and tau interact in vivo to promote the aggregation and accumulation of each other.<\/jats:p>","DOI":"10.3233\/jad-201038","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T22:00:05Z","timestamp":1613253605000},"page":"885-893","source":"Crossref","is-referenced-by-count":20,"title":["\u03b1-Synuclein Heteromers in Red Blood Cells of Alzheimer\u2019s Disease and Lewy Body Dementia Patients"],"prefix":"10.1177","volume":"80","author":[{"given":"Simona","family":"Daniele","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Baldacci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 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