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The manuscript focuses on the molecular mechanisms of glutamatergic, GABA, and cholinergic synapses altered by the presence of amyloid-\u03b2 aggregates and hyperphosphorylated tau, as well as on several consequences of the disruption of cellular processes linked to neuronal transport that is controlled by the JNK-JIP (c-jun NH2-terminal kinase (JNK)\u2013interacting proteins (JIPs) complex, including the transport of A\u03b2PP or autophagosomes.<\/jats:p>","DOI":"10.3233\/jad-201053","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T09:48:12Z","timestamp":1605865692000},"page":"S127-S139","source":"Crossref","is-referenced-by-count":13,"title":["c-Jun N-Terminal Kinases in Alzheimer\u2019s Disease: A Possible Target for the Modulation of the Earliest Alterations"],"prefix":"10.1177","volume":"82","author":[{"given":"Oriol","family":"Busquets","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry; Pharmacy and Food Sciences Faculty, Universitat de Barcelona, Barcelona, Spain"},{"name":"Department of Biochemistry and Biotechnology, Medicine and Health Sciences Faculty, Universitat Rovira i Virgili, Reus, Spain"},{"name":"Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Institut de Neuroci\u00e8ncies, Universitat de Barcelona, Barcelona, Spain"},{"name":"Dominick P. 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