{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:50:36Z","timestamp":1777395036527,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The frontal variant of Alzheimer\u2019s disease (fAD) is poorly understood and poorly defined. The diagnosis remains challenging. The main differential diagnosis is the behavioral variant of frontotemporal degeneration (bvFTD). For fAD, there is some dissociation between the clinical frontal presentation and imaging and neuropathological studies, which do not always find a specific involvement of the frontal lobes. DAPHNE is a behavioral scale, which demonstrated excellent performance to distinguish between bvFTD and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of the present study was to assess the reliability of this new tool to improve the clinical diagnosis of fAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty fAD patients and their caregivers were prospectively included and were compared with 36 bvFTD and 22 AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The three main behavioral disorders in the fAD patients were apathy, loss of empathy, and disinhibition. Three disorders were discriminant because they were less frequent and less severe in the fAD patients than in the bvFTD patients, namely hyperorality, neglect, and perseverations. This specific pattern of behavioral disorders was corroborated by SPECT or\n                      <jats:sup>18<\/jats:sup>\n                      FDG PET-CT scan that showed that patients with fAD could have a medial frontal hypoperfusion, whereas in bvFTD patients the orbitofrontal cortex was the main involved region, with more diffuse hypoperfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We demonstrated that DAPHNE had good sensitivity and good specificity to discriminate between the three groups and in particular between fAD and bvFTD patients. DAPHNE is a quick tool that could help clinicians in memory clinics not only to differentiate bvFTD from typical AD but also from fAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-201088","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:19:14Z","timestamp":1610713154000},"page":"1735-1745","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Improving the Diagnosis of the Frontal Variant of Alzheimer\u2019s Disease with the DAPHNE Scale"],"prefix":"10.1177","volume":"79","author":[{"given":"Elsa","family":"Lehingue","sequence":"first","affiliation":[{"name":"CHU de Lyon, Centre M\u00e9moire Ressource et Recherche (CMRR), Departement de Neurologie cognitive et Service de Neuropsychologie, Universit\u00e9 Lyon 1, and Hospices civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Bron, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Gueniat","sequence":"additional","affiliation":[{"name":"CHU de Dijon, Centre M\u00e9moire Ressource et Recherche (CMRR), CHU de Dijon, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Jourdaa","sequence":"additional","affiliation":[{"name":"CH de Dax, Service G\u00e9riatrie, universit\u00e9 Bordeaux 2, Dax, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Beno\u00cet","family":"Hardouin","sequence":"additional","affiliation":[{"name":"INSERM UMR 1246-SPHERE \u201cmethodS in Patient reported outcomes and HEalth REsearch\u201d, Universit\u00e9 de Nantes, Universit\u00e9 de Tours, France"},{"name":"Plateforme de M\u00e9thodologie et Biostatistique - Direction de la Recherche et de l\u2019innovation - CHU Nantes, 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