{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:39:20Z","timestamp":1791031160399,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T00:00:00Z","timestamp":1306713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2011,5,30]]},"abstract":"<jats:p>\n                    The most recent late-onset Alzheimer's disease (LOAD) genome-wide association study revealed genome-wide significant association of two new loci: rs744373 near BIN1 (p = 1.6 \u00d7 10\n                    <jats:sup>\u221211<\/jats:sup>\n                    ) and rs597668 near EXOC3L2\/BLOC1S3\/MARK4 (p = 6.5 \u00d7 10\n                    <jats:sup>\u22129<\/jats:sup>\n                    ). We have genotyped these variants in a large (3,287 LOAD, 4,396 controls), independent dataset comprising eleven case-control series from the USA and Europe. We performed meta-analyses of the association of these variants with LOAD and also tested for association using logistic regression adjusted by age-at-diagnosis, gender, and APOE \u03b54 status. Meta-analysis results showed no evidence of series heterogeneity and logistic regression analysis successfully replicated the association of BIN1 (rs744373) with LOAD with an odds ratio (OR = 1.17, p = 1.1 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    ) comparable to that previously reported (OR = 1.15). The variant near EXOC3L2 (rs597668) showed only suggestive association with LOAD (p = 0.09) after correcting for the presence of the APOE \u03b54 allele. Addition of our follow-up data to the results previously reported increased the strength of evidence for association with BIN1 (11,825 LOAD, 32,570 controls, rs744373 Fisher combined p = 3.8 \u00d7 10\n                    <jats:sup>\u221220<\/jats:sup>\n                    ). We also tested for epistatic interaction between these variants and APOE \u03b54 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179). No significant interactions between these genes were detected. In summary, we provide additional evidence for the variant near BIN1 (rs744373) as a LOAD risk modifier, but our results indicate that the effect of EXOC3L2 independent of APOE \u03b54 should be studied further.\n                  <\/jats:p>","DOI":"10.3233\/jad-2011-101932","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T04:22:19Z","timestamp":1526444539000},"page":"751-758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Replication of\n                    <i>BIN1<\/i>\n                    Association with Alzheimer's Disease and Evaluation of Genetic Interactions"],"prefix":"10.1177","volume":"24","author":[{"given":"Minerva M.","family":"Carrasquillo","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Belbin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"},{"name":"School of Molecular Medical Sciences, Institute of Genetics, Queens's Medical Centre, University of Nottingham, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talisha A.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina D.","family":"Bisceglio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanggeng","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Crook","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Shane","family":"Pankratz","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid B.","family":"Sando","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Olav's Hospital, Trondheim, Norway"},{"name":"Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan O.","family":"Aasly","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Olav's Hospital, Trondheim, Norway"},{"name":"Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Barcikowska","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew K.","family":"Wszolek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill R.","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"},{"name":"Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA"},{"name":"Mayo Alzheimer Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Molecular Medical Sciences, Institute of Genetics, Queens's Medical Centre, University of Nottingham, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Research Trust Consortium (ART)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Younkin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,5,30]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-2011-101932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-2011-101932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:01:10Z","timestamp":1777370470000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-2011-101932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,30]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,5,30]]}},"alternative-id":["10.3233\/JAD-2011-101932"],"URL":"https:\/\/doi.org\/10.3233\/jad-2011-101932","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/s12035-015-9683-3","asserted-by":"object"}]},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,30]]}}}