{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:30:08Z","timestamp":1792477808840,"version":"4.5.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T00:00:00Z","timestamp":1316390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2011,9,19]]},"abstract":"<jats:p>\n                    Glutamate transporters regulate normal synaptic network interactions and prevent neurotoxicity by rapidly clearing extracellular glutamate. GLT-1, the dominant glutamate transporter in the cerebral cortex and hippocampus, is significantly reduced in Alzheimer's disease (AD). However, the role GLT-1 loss plays in the cognitive dysfunction and pathology of AD is unknown. To determine the significance of GLT-1 dysfunction on AD-related pathological processes, mice lacking one allele for GLT-1(+\/\u2212) were crossed with transgenic mice expressing mutations of the amyloid-\u03b2 protein precursor and presenilin-1 (A\u03b2PPswe\/PS1\u0394E9) and investigated at 6 or 9 months of age. Partial loss of GLT-1 unmasked spatial memory deficits in 6-month-old mice expressing A\u03b2PPswe\/PS1\u0394E9, with these mice also exhibiting an increase in the ratio of detergent-insoluble A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    . At 9 months both behavioral performance and insoluble A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    ratios among GLT-1(+\/+)\/A\u03b2PPswe\/PS1\u0394E9 and GLT-1(+\/\u2212)\/A\u03b2PPswe\/PS1\u0394E9 mice were comparable. These results suggest that deficits in glutamate transporter function compound the effects of familial AD A\u03b2PP\/PS1 mutant transgenes in younger animals and thus may contribute to early occurring pathogenic processes associated with AD.\n                  <\/jats:p>","DOI":"10.3233\/jad-2011-110503","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T04:28:43Z","timestamp":1526444923000},"page":"447-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":152,"title":["GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model"],"prefix":"10.1177","volume":"26","author":[{"given":"Paramita","family":"Mookherjee","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA"},{"name":"Amgen Inc., Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattie S.","family":"Green","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System (VAPSHCS) , Seattle, WA, USA"},{"name":"Department of Medicine, University of Washington School of Medicine, Seattle WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Stennis","family":"Watson","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System (VAPSHCS) , Seattle, WA, USA"},{"name":"Geriatric Research Education and Clinical Center (GRECC), VAPSHCS, Seattle, WA, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos A.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kole D.","family":"Meeker","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center (GRECC), VAPSHCS, Seattle, WA, USA"},{"name":"Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Meabon","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center (GRECC), VAPSHCS, Seattle, WA, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System (VAPSHCS) , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System (VAPSHCS) , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie G.","family":"Olson","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System (VAPSHCS) , Seattle, WA, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA"},{"name":"Mental Illness Research, Education, and Clinical Center (MIRECC), VAPSHCS, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Cook","sequence":"additional","affiliation":[{"name":"Veterans Affairs Puget Sound Health Care System (VAPSHCS) , Seattle, WA, USA"},{"name":"Department of Medicine, University of Washington School of Medicine, Seattle WA, USA"},{"name":"Geriatric Research Education and Clinical Center (GRECC), VAPSHCS, Seattle, WA, USA"},{"name":"Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,9,19]]},"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-2011-110503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-2011-110503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:01:44Z","timestamp":1777370504000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-2011-110503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,19]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9,19]]}},"alternative-id":["10.3233\/JAD-2011-110503"],"URL":"https:\/\/doi.org\/10.3233\/jad-2011-110503","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1155\/2018\/4160247","asserted-by":"object"},{"id-type":"doi","id":"10.1007\/s12035-016-0293-5","asserted-by":"object"}]},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,19]]}}}