{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:55:22Z","timestamp":1777395322197,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:p>Background: Vitamin D deficiency and altered body composition are common in Alzheimer\u2019s disease (AD). Memantine with vitamin D supplementation can protect cortical axons against amyloid-\u03b2 exposure and glutamate toxicity. Objective: To study the effects of vitamin D deprivation and subsequent treatment with memantine and vitamin D enrichment on whole-body composition using a mouse model of AD. Methods: Male APPswe\/PS1dE9 mice were divided into four groups at 2.5 months of age: the control group (n\u200a=\u200a14) was fed a standard diet throughout; the remaining mice were started on a vitamin D-deficient diet at month 6. The vitamin D-deficient group (n\u200a=\u200a14) remained on the vitamin D-deficient diet for the rest of the study. Of the remaining two groups, one had memantine (n\u200a=\u200a14), while the other had both memantine and 10 IU\/g vitamin D (n\u200a=\u200a14), added to their diet at month 9. Serum 25(OH)D levels measured at months 6, 9, 12, and 15 confirmed vitamin D levels were lower in mice on vitamin D-deficient diets and higher in the vitamin D-supplemented mice. Micro-computed tomography was performed at month 15 to determine whole-body composition. Results: In mice deprived of vitamin D, memantine increased bone mineral content (8.7% increase, p\u200a&lt;\u200a0.01) and absolute skeletal tissue mass (9.3% increase, p\u200a&lt;\u200a0.05) and volume (9.2% increase, p\u200a&lt;\u200a0.05) relative to controls. This was not observed when memantine treatment was combined with vitamin D enrichment. Conclusion: Combination treatment of vitamin D and memantine had no negative effects on body composition. Future studies should clarify whether vitamin D status impacts the effects of memantine treatment on bone physiology in people with AD.<\/jats:p>","DOI":"10.3233\/jad-201137","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T14:13:23Z","timestamp":1616508803000},"page":"375-388","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Memantine Treatment and Combination with Vitamin D Supplementation on Body Composition in the APP\/PS1 Mouse Model of Alzheimer\u2019s Disease Following Chronic Vitamin D Deficiency"],"prefix":"10.1177","volume":"81","author":[{"given":"Dickson","family":"Wong","sequence":"first","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana N.","family":"Broberg","sequence":"additional","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"},{"name":"Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagroop","family":"Doad","sequence":"additional","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph U.","family":"Umoh","sequence":"additional","affiliation":[{"name":"Preclinical Imaging Research Centre, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Bellyou","sequence":"additional","affiliation":[{"name":"Centre for Functional and Metabolic Mapping, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J. 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