{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:16:07Z","timestamp":1788020167880,"version":"build-2784847793"},"reference-count":134,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,3,9]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is becoming a prevalent disease in the elderly population. Past decades have witnessed the development of drug therapies with varying targets. However, all drugs with a single molecular target fail to reverse or ameliorate AD progression, which ultimately results in cortical and subcortical network dysregulation. Deep brain stimulation (DBS) has been proven effective for the treatment of Parkinson\u2019s disease, essential tremor, and other neurological diseases. As such, DBS has also been gradually acknowledged as a potential therapy for AD. The current review focuses on DBS of the nucleus basalis of Meynert (NBM). As a critical component of the cerebral cholinergic system and the Papez circuit in the basal ganglia, the NBM plays an indispensable role in the subcortical regulation of memory, attention, and arousal state, which makes the NBM a promising target for modulation of neural network dysfunction and AD treatment. We summarized the intricate projection relations and functionality of the NBM, current approaches for stereotactic localization and evaluation of the NBM, and the therapeutic effects of NBM-DBS both in patients and animal models. Furthermore, the current shortcomings of NBM-DBS, such as variations in cortical blood flow, increased temperature in the target area, and stimulation-related neural damage, were presented.<\/jats:p>","DOI":"10.3233\/jad-201141","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T13:01:49Z","timestamp":1611061309000},"page":"53-70","source":"Crossref","is-referenced-by-count":17,"title":["Deep Brain Stimulation in Alzheimer\u2019s Disease: Targeting the Nucleus Basalis of Meynert"],"prefix":"10.1177","volume":"80","author":[{"given":"Yu-si","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-cong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-201141_ref1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD 2016 Dementia Collaborators","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-201141_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/NEN.0b013e3181919a48","article-title":"Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship","volume":"68","author":"Nelson","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-201141_ref3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-011-0826-y","article-title":"Alzheimer\u2019s disease is not \u201cbrain aging\u201d: Neuropathological, genetic, and epidemiological human studies","volume":"121","author":"Nelson","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-201141_ref4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/ajag.12330","article-title":"Clinical Practice Guidelines for Dementia in Australia: A step towards improving uptake of research findings in health- and aged-care settings","volume":"35","author":"Guideline Adaptation Committee","year":"2016","journal-title":"Australas J Ageing"},{"key":"10.3233\/JAD-201141_ref5","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1468-1331.2010.03040.x","article-title":"EFNS guidelines for the diagnosis and management of Alzheimer\u2019s disease","volume":"17","author":"Hort","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-201141_ref7","doi-asserted-by":"crossref","first-page":"JC6","DOI":"10.7326\/0003-4819-156-12-201206190-02010","article-title":"ACP Journal Club. 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