{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:14:59Z","timestamp":1790039699305,"version":"4.0.1"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,3,9]]},"abstract":"<jats:p>Background: In clinical practice, the amy-PET is globally inspected to provide a binary outcome, but the role of a regional assessment has not been fully investigated yet. Objective: To deepen the role of regional amyloid burden and its implication on clinical-neuropsychological features. Materials: Amy-PET and a complete neuropsychological assessment (Trail Making Test, Rey Auditory Verbal Learning Test, semantic verbal fluency, Symbol Digit, Stroop, visuoconstruction) were available in 109 patients with clinical suspicion of Alzheimer\u2019s disease. By averaging the standardized uptake value ratio and ELBA, a regional quantification was calculated for each scan. Patients were grouped according to their overall amyloid load: correlation maps, based on regional quantification, were calculated and compared. A regression analysis between neuropsychological assessment and the regional amyloid-\u03b2 (A\u03b2) load was carried out. Results: Significant differences were observed between the correlation maps of patients at increasing levels of A\u03b2 and the overall dataset. The A\u03b2 uptake of the subcortical gray matter resulted not related to other brain regions independently of the global A\u03b2 level. A significant association of semantic verbal fluency was observed with ratios of cortical and subcortical distribution of A\u03b2 which represent a coarse measure of differences in regional distribution of A\u03b2. Conclusion: Our observations confirmed the different susceptibility to A\u03b2 accumulation among brain regions. The association between cognition and A\u03b2 distribution deserves further investigations: it is possibly due to a direct local effect or it represents a proxy marker of a more aggressive disease subtype. Regional A\u03b2 assessment represents an available resource on amy-PET scan with possibly clinical and prognostic implications.<\/jats:p>","DOI":"10.3233\/jad-201156","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T18:57:18Z","timestamp":1612292238000},"page":"383-396","source":"Crossref","is-referenced-by-count":5,"title":["Probing the Role of a Regional Quantitative Assessment of Amyloid PET"],"prefix":"10.1177","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-8101","authenticated-orcid":false,"given":"Enrico","family":"Peira","sequence":"first","affiliation":[{"name":"INFN, Genoa, Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Child and Maternal Health (DINOGMI), University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Grazzini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, 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