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A healthy nervous system is endowed with synaptic plasticity, among others neural plasticity mechanisms, allowing structural and physiological adaptations to changes in the environment. This neural plasticity modification sustains learning and memory, and behavioral changes and is severely affected by pathological and aging conditions, leading to cognitive deterioration. This article reviews critical aspects of AD neurodegeneration as well as therapeutic approaches that restore neural plasticity to provide functional recoveries, including environmental enrichment, physical exercise, transcranial stimulation, neurotrophin involvement, and direct electrical stimulation of the amygdala. In addition, we report recent behavioral results in\n                    <jats:italic toggle=\"yes\">Octodon degus<\/jats:italic>\n                    , a promising natural model for the study of AD that naturally reproduces the neuropathological alterations observed in AD patients during normal aging, including neuronal toxicity, deterioration of neural plasticity, and the decline of learning and memory.\n                  <\/jats:p>","DOI":"10.3233\/jad-201178","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:19:29Z","timestamp":1610713169000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Alzheimer\u2019s Disease, Neural Plasticity, and Functional Recovery"],"prefix":"10.1177","volume":"82","author":[{"given":"Daymara","family":"Mercer\u00f3n-Mart\u00ednez","sequence":"first","affiliation":[{"name":"International Center for Neurological Restoration (CIREN)","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Ibaceta-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Universidad de Valpara\u00edso","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Salazar","sequence":"additional","affiliation":[{"name":"Universidad de Valpara\u00edso","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Almaguer-Melian","sequence":"additional","affiliation":[{"name":"International Center for Neurological Restoration (CIREN)","place":["Cuba"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Bergado-Rosado","sequence":"additional","affiliation":[{"name":"Universidad del Sin\u00fa","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian G.","family":"Palacios","sequence":"additional","affiliation":[{"name":"Universidad de Valpara\u00edso","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05554.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70232-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006247"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.02.001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3114"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.45.1.435"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.1999.10.1.15"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(20000401)60:1<65::AID-JNR7>3.0.CO;2-Q"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(01)02285-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-001-0105-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00524-8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2002.10302.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0731-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03437-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-016-0072-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.emo071357"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12226"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135499"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00161"},{"key":"e_1_3_3_22_2","first-page":"1074","article-title":"[Cellular mechanisms of neuroplasticity]","volume":"31","author":"Bergado-Rosado JA","year":"2000","unstructured":"Bergado-RosadoJA, Almaguer-MelianW (2000) [Cellular mechanisms of neuroplasticity]. 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