{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:53:53Z","timestamp":1777395233865,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Individuals who participated in response efforts at the World Trade Center (WTC) following 9\/11\/2001 are experiencing elevated incidence of mild cognitive impairment (MCI) at midlife.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We hypothesized that white matter connectivity measured using diffusion spectrum imaging (DSI) would be restructured in WTC responders with MCI versus cognitively unimpaired responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty responders (mean age 56; 10 MCI\/10 unimpaired) recruited from an epidemiological study were characterized using NIA-AA criteria alongside controls matched on demographics (age\/sex\/occupation\/race\/education). Axial DSI was acquired on a 3T Siemen\u2019s Biograph mMR scanner (12-channel head coil) using a multi-band diffusion sequence. Connectometry examined whole-brain tract-level differences in white matter integrity. Fractional anisotropy (FA), mean diffusivity (MD), and quantified anisotropy were extracted for region of interest (ROI) analyses using the Desikan-Killiany atlas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Connectometry identified both increased and decreased connectivity within regions of the brains of responders with MCI identified in the corticothalamic pathway and cortico-striatal pathway that survived adjustment for multiple comparisons. MCI was also associated with higher FA values in five ROIs including in the rostral anterior cingulate; lower MD values in four ROIs including the left rostral anterior cingulate; and higher MD values in the right inferior circular insula. Analyses by cognitive domain revealed nominal associations in domains of response speed, verbal learning, verbal retention, and visuospatial learning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>WTC responders with MCI at midlife showed early signs of neurodegeneration characterized by both increased and decreased white matter diffusivity in regions commonly affected by early-onset Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-201237","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T12:19:55Z","timestamp":1614341995000},"page":"1209-1219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["White Matter Connectivity in Incident Mild Cognitive Impairment: A Diffusion Spectrum Imaging Study of World Trade Center Responders at Midlife"],"prefix":"10.1177","volume":"80","author":[{"given":"Chuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"},{"name":"Department of Radiology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minos","family":"Kritikos","sequence":"additional","affiliation":[{"name":"Program in Public Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"},{"name":"Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean A.P.","family":"Clouston","sequence":"additional","affiliation":[{"name":"Program in Public Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"},{"name":"Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Deri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"},{"name":"World Trade Center Health and Wellness Program, Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Serrano-Sosa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lev","family":"Bangiyev","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Santiago-Michels","sequence":"additional","affiliation":[{"name":"Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"},{"name":"World Trade Center Health and Wellness Program, Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Gandy","sequence":"additional","affiliation":[{"name":"Center for Cognitive Health and NFL Neurological Care, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Mount Sinai Alzheimer\u2019s Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA"},{"name":"Center for Cognitive Health and NFL Neurological Care, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn J.","family":"Bromet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Luft","sequence":"additional","affiliation":[{"name":"Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"},{"name":"World Trade Center Health and Wellness Program, Stony Brook University, Stony Brook, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa013404"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002184"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.07.006"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.1.96"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318245d295"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz057"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160090"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132593"},{"key":"ref010","doi-asserted-by":"crossref","unstructured":"YangF, ChowdhurySR, JacobsHI, JohnsonKA, DuttaJ (2019) A longitudinal model for tau aggregation in Alzheimer\u2013s disease based on structural connectivity. In International Conference on Information Processing in Medical Imaging, Springer, pp.  384\u2013393.","DOI":"10.1007\/978-3-030-20351-1_29"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00261"},{"key":"ref012","unstructured":"Centers for Disease Control and Prevention, World Trade Center Health Program At A Glance, https:\/\/www.cdc.gov\/wtc\/ataglance.html, Accessed March 22, 2017."},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv099"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4756"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2014.11.003"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp010"},{"key":"ref019","doi-asserted-by":"crossref","unstructured":"FirstMB (2014) Structured clinical interview for the DSM (SCID). In The Encyclopedia of Clinical Psychology, John Wiley & Sons, Inc., pp. 1\u20136.","DOI":"10.1002\/9781118625392.wbecp351"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.033"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.06.021"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2045126"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26143"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.053"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080713"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"ref027","first-page":"336","volume":"2016","author":"Gaser C","year":"2016","journal-title":"HBM"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.10.006"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-013-0197-3"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141839"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2017.10.007"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1145"},{"key":"ref034","doi-asserted-by":"crossref","unstructured":"ZahodneLB, Reuter-LorenzPA (2019) Compensation and brain aging:Areviewand analysis of evidence. In\n                      The Aging Brain: Functional Adaptation Across Adulthood\n                      . American Psychological Association, pp. 185-216.","DOI":"10.1037\/0000143-008"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.219"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1038\/35077500"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.1.256"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19970901)49:5<515::AID-JNR1>3.0.CO;2-E"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03474.x"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23109"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00742"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135256"},{"key":"ref043","unstructured":"BlissT (2007) The hippocampus book, Oxford University Press, New York, NY, US."},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3958-09.2009"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.015"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.08.006"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.14259\/as.v2i1.171"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.17744\/mehc.39.1.06"},{"key":"ref049","doi-asserted-by":"publisher","DOI":"10.33043\/JSACP.3.1.103-116"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-201237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-201237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-201237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:15Z","timestamp":1777370715000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-201237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4,6]]}},"alternative-id":["10.3233\/JAD-201237"],"URL":"https:\/\/doi.org\/10.3233\/jad-201237","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,25]]}}}