{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:19:32Z","timestamp":1787170772685,"version":"build-2736575974"},"reference-count":74,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>Background: Older adults living with amnestic mild cognitive impairment (aMCI) not only demonstrate impairments in Theory of Mind (ToM), relative to adults with non-amnestic MCI (naMCI), but are also at a higher risk of developing dementia. Objective: Our primary objective was to ascertain whether default mode network (DMN) functional connectivity was differentially associated with ToM abilities between MCI subgroups. Methods: Using functional magnetic resonance imaging, we investigated alterations in resting-state functional connectivity within the brain\u2019s DMN in a sample of 43 older adults with aMCI (n\u200a=\u200a19) and naMCI (n\u200a=\u200a24), previously reported to demonstrate poorer ToM abilities. Results: Compared to naMCI, the aMCI subgroup revealed a significant association between poorer ToM performance and reduced functional connectivity between the bilateral temporal pole (TempP) and the left lateral temporal cortex (LTC) (LTC_L-TempP_L: b\u200a=\u200a\u20130.06, t(33)\u200a=\u200a\u20133.53, p\u200a=\u200a0.02; LTC_L-TempP_R: b\u200a=\u200a\u20130.07,t(33)\u200a=\u200a\u20133.20, p\u200a=\u200a0.03); between the right TempP and the dorsal medial prefrontal cortex (dMPFC) (b\u200a=\u200a\u20130.04, t(33)\u200a=\u200a\u20133.02, p\u200a=\u200a0.03) and between the left and right TempP (b\u200a=\u200a\u20130.05, t(33)\u200a=\u200a\u20133.26, p\u200a=\u200a0.03). In the naMCI subgroup, the opposite relationship was present between the bilateral TempP and the left LTC (Combined correlation: r\u200a=\u200a\u20130.47, p\u200a=\u200a0.02), however, not between the right TempP and the dMPFC (r\u200a=\u200a\u20130.14, p\u200a=\u200a0.51) or the left and right TempP (r\u200a=\u200a\u20130.31, p\u200a=\u200a0.14). Conclusion: Our findings suggest that alterations in functional connectivity within the DMN involving temporal and frontal lobe regions are associated with ToM deficits in aMCI.<\/jats:p>","DOI":"10.3233\/jad-201284","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T13:00:49Z","timestamp":1617714049000},"page":"1079-1091","source":"Crossref","is-referenced-by-count":9,"title":["Poorer Theory of Mind in Amnestic Mild Cognitive Impairment Is Associated with Decreased Functional Connectivity in the Default Mode Network"],"prefix":"10.1177","volume":"81","author":[{"given":"Johannes C.","family":"Michaelian","sequence":"first","affiliation":[{"name":"School of Psychology, University of Sydney, Sydney, Australia"},{"name":"Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, Australia"},{"name":"Brain and Mind Centre, University of Sydney, Sydney, Australia"},{"name":"Charles Perkins Centre, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantel L.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, Australia"},{"name":"Charles Perkins Centre, University of Sydney, Sydney, Australia"},{"name":"School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"Mowszowski","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Sydney, Sydney, Australia"},{"name":"Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, Australia"},{"name":"Brain and Mind Centre, University of Sydney, Sydney, Australia"},{"name":"Charles Perkins Centre, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Guastella","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, Children\u2019s Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"McCade","sequence":"additional","affiliation":[{"name":"Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"McKinnon","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Sydney, Sydney, Australia"},{"name":"Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, Australia"},{"name":"Brain and Mind Centre, University of Sydney, Sydney, Australia"},{"name":"Charles Perkins Centre, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon 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