{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:45:07Z","timestamp":1787244307296,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The utility of subjective cognitive decline (SCD) as an indicator of preclinical AD is overshadowed by its inconsistent association with objective cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study examines if manipulations of SCD measurement affect its association with early cognitive dysfunction characteristic of preclinical AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cognitively healthy older adults ( n\u200a=\u200a110) completed SCD questionnaires that elicited complaints in general, compared to 5 years ago (retrospective SCD) and compared to their peers (age-anchored SCD) in binary and Likert scales. Outcome cognitive tasks included an associative memory task (Face-Name Test), a visual short-term memory binding task (STMB test), and a clinical neuropsychological list learning test (Selective Reminder Test).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>SCD complaints, when compared to age-matched peers (age-anchored SCD) were endorsed less frequently than complaints compared to 5 years ago (retrospective SCD) ( p\u200a&lt;\u200a0.01). In demographically adjusted regressions, age-anchored ordinal-rated SCD was associated with short term memory binding (\u03b2=\u200a\u20130.22, p\u200a=\u200a0.040, CI\u200a=\u200a\u20130.45, \u20130.01), associative memory (\u03b2=\u200a\u20130.26, p\u200a=\u200a0.018, CI\u200a=\u200a\u20130.45, \u20130.06), and list learning (\u03b2=\u200a\u20130.31, p\u200a=\u200a0.002, CI\u200a=\u200a\u20130.51, \u20130.12). Retrospective and general ordinal-rated SCD was associated with associative memory (\u03b2=\u200a\u20130.25, p\u200a=\u200a0.012, CI\u200a=\u200a\u20130.44, \u20130.06; \u03b2=\u200a\u20130.29, p\u200a=\u200a0.003, CI\u200a=\u200a\u20130.47, \u20130.10) and list learning only (\u03b2=\u200a\u20130.25, p\u200a=\u200a0.014, CI\u200a=\u200a\u20130.45, \u20130.05; \u03b2=\u200a\u20130.28, p\u200a=\u200a0.004, CI\u200a=\u200a\u20130.48, \u20130.09).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Ordinal age-anchored SCD appears better suited than other SCD measurements to detect early cognitive dysfunction characteristic of preclinical AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-201322","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T12:21:13Z","timestamp":1614342073000},"page":"1185-1196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Optimizing Subjective Cognitive Decline to Detect Early Cognitive Dysfunction"],"prefix":"10.1177","volume":"80","author":[{"given":"Silvia","family":"Chapman","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience Division, Columbia University Medical Center, New York, NY, USA"},{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Sunderaraman","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division, Columbia University Medical Center, New York, NY, USA"},{"name":"Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA"},{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA"},{"name":"Department of Neurology, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division, Columbia University Medical Center, New York, NY, USA"},{"name":"Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Azar","sequence":"additional","affiliation":[{"name":"Department of Psychology, Drexel University, Philadelphia, PA, USA"},{"name":"VA Boston Health Care System, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh E.","family":"Colvin","sequence":"additional","affiliation":[{"name":"VA Boston Health Care System, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan S.","family":"Barker","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division, Columbia University Medical Center, New York, NY, USA"},{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"McKeague","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Kreisl","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division, Columbia University Medical Center, New York, NY, USA"},{"name":"Gertrude H. 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