{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:47:17Z","timestamp":1791820037457,"version":"4.3.4"},"reference-count":99,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,4,20]]},"abstract":"<jats:p>Background: Non-Hispanic black (NHB) individuals have increased risk of Alzheimer\u2019s disease (AD) relative to non-Hispanic whites (NHW). Ethnicity\/race can serve as a proxy sociodemographic variable for a complex representation of sociocultural and environmental factors. Chronic pain is a form of stress with high prevalence and sociodemographic disparities. Chronic pain is linked to lower cognition and accelerated biological aging. Objective: The purpose of this study is to seek understanding of potential cognitive and temporal lobe structural brain AD vulnerabilities based on chronic pain stage and ethnicity\/race. Methods: Participants included 147 community dwelling NHB and NHW adults without dementia between 45\u201385 years old who had or were at risk of knee osteoarthritis. All participants received an MRI (3T Philips), the Montreal Cognitive Assessment (MoCA), and assessment of clinical knee pain stage. Results: There were ethnic\/race group differences in MoCA scores but no relationships with chronic knee pain stage. Ethnicity\/race moderated the relationship between AD-related temporal lobe thickness and chronic pain stage with quadratic patterns suggesting thinner cortex in high chronic pain stage NHB adults. Conclusion: There appear to be complex relationships between chronic knee pain stage, temporal lobe cortex, and sociodemographic variables. Specifically, NHB participants without dementia but with high chronic knee pain stage appeared to have thinner temporal cortex in areas associated with AD. Understanding the effects of sociocultural and socioeconomic factors on health outcomes is the first step to challenging the disparities in healthcare that now appear to link disease conditions to neurodegenerative processes.<\/jats:p>","DOI":"10.3233\/jad-201345","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T13:00:17Z","timestamp":1615294817000},"page":"1539-1551","source":"Crossref","is-referenced-by-count":27,"title":["Relationships Between Chronic Pain Stage, Cognition, Temporal Lobe Cortex, and Sociodemographic Variables"],"prefix":"10.1177","volume":"80","author":[{"given":"Jared J.","family":"Tanner","sequence":"first","affiliation":[{"name":"Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Hanchate","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA"},{"name":"Department of Anesthesiology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Garvan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Staud","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrishikesh","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burel R.","family":"Goodin","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger B.","family":"Fillingim","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA"},{"name":"Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly T.","family":"Sibille","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Florida, Gainesville, FL, USA"},{"name":"Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA"},{"name":"Department of Aging & Geriatric Research, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-201345_ref1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jalz.2015.12.007","article-title":"Inequalities in dementia incidence between six racial and ethnic groups over 14 years","volume":"12","author":"Mayeda","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-201345_ref2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jalz.2016.06.2360","article-title":"Systematic review of 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