{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:24:04Z","timestamp":1788319444911,"version":"build-2803163510"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:p>Background: Vascular disease is a risk factor for Alzheimer\u2019s disease (AD) and related dementia in older adults. Retinal artery\/vein occlusion (RAVO) is an ophthalmic complication of systemic vascular pathology. Whether there are associations between RAVO and dementia risk is unknown. Objective: To determine whether RAVOs are associated with an increased risk of developing vascular dementia or AD. Methods: Data from Adult Changes in Thought (ACT) study participants were analyzed. This prospective, population-based cohort study followed older adults (age \u226565 years) who were dementia-free at enrollment for development of vascular dementia or AD based on research criteria. RAVO diagnoses were extracted from electronic medical records. Cox-regression survival analyses were stratified by APOE \u025b4 genotype and adjusted for demographic and clinical factors. Results: On review of 41,216 person-years (4,743 participants), 266 (5.6%) experienced RAVO. APOE \u025b4 carriers who developed RAVO had greater than four-fold higher risk for developing vascular dementia (Hazard Ratio [HR] 4.54, 95% Confidence Interval [CI] 1.86, 11.10, p\u200a=\u200a0.001). When including other cerebrovascular disease (history of carotid endarterectomy or transient ischemic attack) in the model, the risk was three-fold higher (HR 3.06, 95% CI 1.23, 7.62). No other conditions evaluated in the secondary analyses were found to confound this relationship. There was no effect in non-APOE \u025b4 carriers (HR 1.03, 95% CI 0.37, 2.80). There were no significant associations between RAVO and AD in either APOE group. Conclusion: Older dementia-free patients who present with RAVO and carry the APOE \u025b4 allele appear to be at higher risk for vascular dementia.<\/jats:p>","DOI":"10.3233\/jad-201492","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T14:18:47Z","timestamp":1615904327000},"page":"245-253","source":"Crossref","is-referenced-by-count":24,"title":["Associations Between Retinal Artery\/Vein Occlusions and Risk of Vascular Dementia"],"prefix":"10.1177","volume":"81","author":[{"given":"Cecilia S.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura 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