{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:43:22Z","timestamp":1788371002257,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,3,9]]},"abstract":"<jats:p>Background: Cerebral microbleeds (CMBs) in patients with Parkinson\u2019s disease (PD) or dementia with Lewy bodies (DLB) have not been adequately studied. Objective: This study aims to find a difference in the total number, prevalence, and common locations of CMBs between PD and DLB and evaluate 99\u00a0mTc-ECD SPECT subtraction images of these two diseases. Methods: We examined 112 patients with PD (53 males and 59 females; age: 77.4\u00b13.6 years) and 28 age-matched patients with DLB (15 males and 13 females; age: 77.1\u00b16.7 years) using brain magnetic resonance imaging (MRI) and 99\u00a0mTc-ECD SPECT subtraction imaging. Results: The total number of CMBs was higher in patients with DLB (41.2%) than in those with PD (11.5%), and the prevalence was significantly higher in the former (0.7\u00b11.1) than the latter (0.2\u00b10.5, p\u200a&lt;\u200a0.05). The odds ratio was 5.4 (95% confidence interval [CI]: 1.7\u201317.4). Furthermore, CMBs were commonly located in the basal ganglia of patients with PD (6 out of 87 patients) but in the occipital lobe of patients with DLB (8 out of 17 patients). 99\u00a0mTc-ECD SPECT subtraction imaging indicated lower cerebral blood flow in the posterior cingulate gyrus among the patients with CMB-positive DLB than among those with CMB-positive PD; additionally, the cerebral blood flow was lower in the bilateral basal ganglia and midbrain among patients with CMB-positive DLB compared to those with CMB-negative DLB. Conclusion: A reduction in occipital glucose metabolism may be related to CMBs in the occipital lobe of patients with DLB.<\/jats:p>","DOI":"10.3233\/jad-201495","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T12:44:42Z","timestamp":1611665082000},"page":"331-335","source":"Crossref","is-referenced-by-count":13,"title":["Cerebral Microbleeds in Patients with Parkinson\u2019s Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99\u00a0mTc-ECD SPECT Subtraction Imaging"],"prefix":"10.1177","volume":"80","author":[{"given":"Mami","family":"Takemoto","sequence":"first","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Omote","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Morihara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kita-ku, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-201495_ref1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/bs.pmbts.2019.07.009","article-title":"PD and DLB: Brain imaging in Parkinson\u2019s disease and dementia with Lewy bodies","volume":"165","author":"Berman","year":"2019","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.3233\/JAD-201495_ref2","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.parkreldis.2015.06.019","article-title":"The prevalence and risk factors of cerebral microbleeds in patients with Parkinson\u2019s disease","volume":"21","author":"Yamashiro","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"key":"10.3233\/JAD-201495_ref3","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00415-020-09736-0","article-title":"Microbleeds in dementia with Lewy bodies","volume":"267","author":"Donaghy","year":"2020","journal-title":"J Neurol"},{"key":"10.3233\/JAD-201495_ref4","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord"},{"key":"10.3233\/JAD-201495_ref5","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"10.3233\/JAD-201495_ref6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. 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