{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:34:06Z","timestamp":1780468446361,"version":"3.54.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>Background: Dementia is one of the strongest predictors of admission to a 24-hour care facility among older people, and 24-hour care is the major cost of Alzheimer\u2019s disease (AD). Objective: The aim of this study was to evaluate the association of early start of anti-dementia medication and other predisposing factors with 2-year risk of transition to 24-hour care in the nationwide cohort of Finnish AD patients. Methods: This was a retrospective, non-interventional study based on individual-level data from Finnish national health and social care registers. The incident cohort included 7,454 AD patients (ICD-10, G30) comprised of two subgroups: those living unassisted at home (n\u200a=\u200a5,002), and those receiving professional home care (n\u200a=\u200a2,452). The primary outcome was admission to a 24-hour care facility. Exploratory variables were early versus late anti-dementia medication start, sociodemographic variables, care intensity level, and comorbidities. Results: Early anti-dementia medication reduced the risk of admission to 24-hour care both in patients living unassisted at home, with a hazard ratio (HR) of 0.58 (p\u200a&lt;\u200a0.001), and those receiving professional home care (HR, 0.84; p\u200a=\u200a0.039). Being unmarried (HR, 1.69; p\u200a&lt;\u200a0.001), having an informal caregiver (HR, 1.69; p\u200a=\u200a0.003), or having a diagnosis of additional neurological disorder (HR, 1.68; p\u200a=\u200a0.006) or hip fracture (HR, 1.61; p\u200a=\u200a0.004) were associated with higher risk of admission to 24-hour care in patients living unassisted at home. Conclusion: To support living at home, early start of anti-dementia medication should be a high priority in newly diagnosed AD patients.<\/jats:p>","DOI":"10.3233\/jad-201502","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T13:01:16Z","timestamp":1617714076000},"page":"1103-1115","source":"Crossref","is-referenced-by-count":8,"title":["Early Start of Anti-Dementia Medication Delays Transition to 24-Hour Care in Alzheimer\u2019s Disease Patients: A Finnish Nationwide Cohort Study"],"prefix":"10.1177","volume":"81","author":[{"given":"Olli","family":"Halminen","sequence":"first","affiliation":[{"name":"Department of Industrial Engineering and Management, School of Science, Aalto University, Espoo, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"Vesikansa","sequence":"additional","affiliation":[{"name":"MedEngine Oy, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Meht\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"MedEngine Oy, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iiris","family":"H\u00f6rhammer","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering and Management, School of Science, Aalto University, Espoo, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teija","family":"Mikkola","sequence":"additional","affiliation":[{"name":"Ministry of Finance Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri J.","family":"Virta","sequence":"additional","affiliation":[{"name":"Social Insurance Institution Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Ylisaukko-oja","sequence":"additional","affiliation":[{"name":"MedEngine Oy, Helsinki, Finland"},{"name":"Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miika","family":"Linna","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering and Management, School of Science, Aalto University, Espoo, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-201502_ref1","unstructured":"Wimo A , J\u00f6nsson B , Karlsson G , Winblad B (1998) Health economics of dementia. John Wiley & Sons, Chichester."},{"key":"10.3233\/JAD-201502_ref2","unstructured":"Prince M , Wimo A , Guerchet M , Ali GC , Wu Y PA (2015) World Alzheimer Report 2015. The global impact of dementia: An analysis of prevalence, incidence, costs and trends. 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Validity of dementia and Alzheimer\u2019s disease diagnoses in Finnish national registers","volume":"10","author":"Solomon","year":"2014","journal-title":"Alzheimers Dement"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-201502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:42Z","timestamp":1777370742000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-201502"}},"subtitle":[],"editor":[{"given":"Sophie","family":"Vandepitte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":28,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-201502","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}